OMIA:002405-9913 : Stature, PLAG1-related in Bos taurus (taurine cattle)
Categories: Growth / size / body region phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 603026 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: no
Mode of inheritance: Multifactorial
Considered a defect: no
Key variant known: no
Species-specific description: Utsunomiya et al. 2017: "Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16th and 18th centuries. Towards the 19th and 20th centuries, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait."
Have human generated variants been created, e.g. through genetic engineering and gene editing
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|PLAG1||PLAG1 zinc finger||Bos taurus||14||NC_037341.1 (23375679..23323709)||PLAG1||Homologene, Ensembl , NCBI gene|
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Caivio-Nasner, S., López-Herrera, A., González-Herrera, L.G., Rincón, J.C. :|
|Frequency of genotypic markers for genetic disorders, colour, polledness, and major genes in Blanco Orejinegro cattle. Trop Anim Health Prod 53:546, 2021. Pubmed reference: 34779908. DOI: 10.1007/s11250-021-02990-y.|
|2017||Utsunomiya, Y.T., Milanesi, M., Utsunomiya, A.T.H., Torrecilha, R.B.P., Kim, E.S., Costa, M.S., Aguiar, T.S., Schroeder, S., do Carmo, A.S., Carvalheiro, R., Neves, H.H.R., Padula, R.C.M., Sussai, T.S., Zavarez, L.B., Cipriano, R.S., Caminhas, M.M.T., Hambrecht, G., Colli, L., Eufemi, E., Ajmone-Marsan, P., Cesana, D., Sannazaro, M., Buora, M., Morgante, M., Liu, G., Bickhart, D., Van Tassell, C.P., Sölkner, J., Sonstegard, T.S., Garcia, J.F. :|
|A PLAG1 mutation contributed to stature recovery in modern cattle. Sci Rep 7:17140, 2017. Pubmed reference: 29215042. DOI: 10.1038/s41598-017-17127-1.|
|2013||Fortes, M.R., Kemper, K., Sasazaki, S., Reverter, A., Pryce, J.E., Barendse, W., Bunch, R., McCulloch, R., Harrison, B., Bolormaa, S., Zhang, Y.D., Hawken, R.J., Goddard, M.E., Lehnert, S.A. :|
|Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattle. Anim Genet , 2013. Pubmed reference: 23909810. DOI: 10.1111/age.12075.|
- Created by Imke Tammen2 on 28 Aug 2021
- Changed by Imke Tammen2 on 28 Aug 2021