OMIA 002405-9913 : Stature, PLAG1-related in Bos taurus

Possibly relevant human trait(s) and/or gene(s) (MIM number): 603026 (gene)

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: no

Key variant known: no

Species-specific description: Utsunomiya et al. 2017: "Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16th and 18th centuries. Towards the 19th and 20th centuries, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
PLAG1 PLAG1 zinc finger Bos taurus 14 NC_037341.1 (23375661..23323709) PLAG1 Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Caivio-Nasner, S., López-Herrera, A., González-Herrera, L.G., Rincón, J.C. :
Frequency of genotypic markers for genetic disorders, colour, polledness, and major genes in Blanco Orejinegro cattle. Trop Anim Health Prod 53:546, 2021. Pubmed reference: 34779908. DOI: 10.1007/s11250-021-02990-y.
2017 Utsunomiya, Y.T., Milanesi, M., Utsunomiya, A.T.H., Torrecilha, R.B.P., Kim, E.S., Costa, M.S., Aguiar, T.S., Schroeder, S., do Carmo, A.S., Carvalheiro, R., Neves, H.H.R., Padula, R.C.M., Sussai, T.S., Zavarez, L.B., Cipriano, R.S., Caminhas, M.M.T., Hambrecht, G., Colli, L., Eufemi, E., Ajmone-Marsan, P., Cesana, D., Sannazaro, M., Buora, M., Morgante, M., Liu, G., Bickhart, D., Van Tassell, C.P., Sölkner, J., Sonstegard, T.S., Garcia, J.F. :
A PLAG1 mutation contributed to stature recovery in modern cattle. Sci Rep 7:17140, 2017. Pubmed reference: 29215042. DOI: 10.1038/s41598-017-17127-1.
2013 Fortes, M.R., Kemper, K., Sasazaki, S., Reverter, A., Pryce, J.E., Barendse, W., Bunch, R., McCulloch, R., Harrison, B., Bolormaa, S., Zhang, Y.D., Hawken, R.J., Goddard, M.E., Lehnert, S.A. :
Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattle. Anim Genet :, 2013. Pubmed reference: 23909810. DOI: 10.1111/age.12075.

Edit History


  • Created by Imke Tammen2 on 28 Aug 2021
  • Changed by Imke Tammen2 on 28 Aug 2021