OMIA:002492-9541 : Amyotrophic lateral sclerosis, TARDBP-related in Macaca fascicularis (crab-eating macaque) |
In other species: Rhesus monkey , pig
Categories: Nervous system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 605078 (gene) , 612069 (trait)
Single-gene trait/disorder: yes
Disease-related: yes
Key variant known: no
Species-specific name: Uchida et al. (2015) "overexpressed wild-type human transactive response deoxyribonucleic acid-binding protein 43 [TARDBP] in spinal cords of cynomolgus monkeys ... by injecting adeno-associated virus vector into the cervical cord, and examined the phenotype using behavioural, electrophysiological, neuropathological and biochemical analyses. These monkeys developed progressive motor weakness and muscle atrophy with fasciculation in distal hand muscles ..." This phene includes references to studies involving genetically modified organisms (GMO)
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
TARDBP | TAR DNA binding protein | Macaca fascicularis | 1 | NC_088375.1 (223794473..223774413) | TARDBP | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002492-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2023 | Zhu, L., Li, S., Li, X.J., Yin, P. : |
Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges. Transl Neurodegener 12:46, 2023. Pubmed reference: 37730668. DOI: 10.1186/s40035-023-00377-7. | |
2021 | Bonifacino, T., Zerbo, R.A., Balbi, M., Torazza, C., Frumento, G., Fedele, E., Bonanno, G., Milanese, M. : |
Nearly 30 years of animal models to study amyotrophic lateral sclerosis: A historical overview and future perspectives. Int J Mol Sci 22:12236, 2021. Pubmed reference: 34830115. DOI: 10.3390/ijms222212236. | |
Yang, W., Chen, X., Li, S., Li, X.J. : | |
Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8. | |
2012 | Uchida, A., Sasaguri, H., Kimura, N., Tajiri, M., Ohkubo, T., Ono, F., Sakaue, F., Kanai, K., Hirai, T., Sano, T., Shibuya, K., Kobayashi, M., Yamamoto, M., Yokota, S., Kubodera, T., Tomori, M., Sakaki, K., Enomoto, M., Hirai, Y., Kumagai, J., Yasutomi, Y., Mochizuki, H., Kuwabara, S., Uchihara, T., Mizusawa, H., Yokota, T. : |
Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43. Brain 135:833-46, 2012. Pubmed reference: 22252998. DOI: 10.1093/brain/awr348. |
Edit History
- Created by Imke Tammen2 on 09 Jan 2022
- Changed by Imke Tammen2 on 22 Sep 2023
- Changed by Imke Tammen2 on 18 Dec 2023