OMIA:002492-9544 : Amyotrophic lateral sclerosis, TARDBP-related in Macaca mulatta (Rhesus monkey)

In other species: crab-eating macaque , pig

Categories: Nervous system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 605078 (gene) , 612069 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
TARDBP TAR DNA binding protein Macaca mulatta 1 NC_041754.1 (213440948..213420789) TARDBP Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002492-9544: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Zhu, L., Li, S., Li, X.J., Yin, P. :
Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges. Transl Neurodegener 12:46, 2023. Pubmed reference: 37730668. DOI: 10.1186/s40035-023-00377-7.
2021 Yang, W., Chen, X., Li, S., Li, X.J. :
Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8.
2019 Yin, P., Guo, X., Yang, W., Yan, S., Yang, S., Zhao, T., Sun, Q., Liu, Y., Li, S., Li, X.J. :
Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains. Acta Neuropathol 137:919-937, 2019. Pubmed reference: 30810811. DOI: 10.1007/s00401-019-01979-0.

Edit History


  • Created by Imke Tammen2 on 09 Jan 2022
  • Changed by Imke Tammen2 on 22 Sep 2023
  • Changed by Imke Tammen2 on 18 Dec 2023