OMIA:002492-9544 : Amyotrophic lateral sclerosis, TARDBP-related in Macaca mulatta (Rhesus monkey) |
In other species: crab-eating macaque , pig
Categories: Nervous system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 605078 (gene) , 612069 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: no
Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| TARDBP | TAR DNA binding protein | Macaca mulatta | 1 | NC_041754.1 (213440948..213420789) | TARDBP | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002492-9544: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Pan, M.T., Zhang, H., Li, X.J., Guo, X.Y. : |
| Genetically modified non-human primate models for research on neurodegenerative diseases. Zool Res 45:2095-8137(2024)02-0263-12:263-274, 2024. Pubmed reference: 38287907. DOI: 10.24272/j.issn.2095-8137.2023.197. | |
| 2023 | Zhu, L., Li, S., Li, X.J., Yin, P. : |
| Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges. Transl Neurodegener 12:46, 2023. Pubmed reference: 37730668. DOI: 10.1186/s40035-023-00377-7. | |
| 2021 | Yang, W., Chen, X., Li, S., Li, X.J. : |
| Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8. | |
| 2019 | Yin, P., Guo, X., Yang, W., Yan, S., Yang, S., Zhao, T., Sun, Q., Liu, Y., Li, S., Li, X.J. : |
| Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains. Acta Neuropathol 137:919-937, 2019. Pubmed reference: 30810811. DOI: 10.1007/s00401-019-01979-0. |
Edit History
- Created by Imke Tammen2 on 09 Jan 2022
- Changed by Imke Tammen2 on 22 Sep 2023
- Changed by Imke Tammen2 on 18 Dec 2023