OMIA 002563-9940 : Melatonin-enriched milk in Ovis aries

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 600950 (gene) , 300015 (gene)

Mendelian trait/disorder: yes

Considered a defect: unknown

Key variant known: yes

Year key variant first reported: 2017

Species-specific description: Ma et al. (2017) used the CRISPR/Cas9 system to produce thirty-four transgenic sheep which can produce melatonin-enriched milk through the integration of exogenous AANAT and/or ASMT genes into their mammary epithelial cells. Seven sheep carried transgenic AANAT, two carried ASMT, and 25 carried both of AANAT and ASMT genes. “In transgenic offspring, the upregulated gene expressions of AANAT and ASMT rendered the elevated melatonin production in milk.”

This phene has been created using genetically modified organisms (GMO). (Entry created by Hannah Edgell, 28/08/2022)

Associated genes:

Symbol Description Species Chr Location OMIA gene details page Other Links
AANAT aralkylamine N-acetyltransferase Ovis aries 11 NC_056064.1 (54630556..54628621) AANAT Homologene, Ensembl, NCBI gene
ASMT acetylserotonin O-methyltransferase Ovis aries X NC_056080.1 (6509510..6484197) ASMT Homologene, Ensembl, NCBI gene


2017 Ma, T., Tao, J., Yang, M., He, C., Tian, X., Zhang, X., Zhang, J., Deng, S., Feng, J., Zhang, Z., Wang, J., Ji, P., Song, Y., He, P., Han, H., Fu, J., Lian, Z., Liu, G. :
An AANAT/ASMT transgenic animal model constructed with CRISPR/Cas9 system serving as the mammary gland bioreactor to produce melatonin-enriched milk in sheep. J Pineal Res 63:, 2017. Pubmed reference: 28273380. DOI: 10.1111/jpi.12406.

Edit History

  • Created by Imke Tammen2 on 24 Aug 2022
  • Changed by Imke Tammen2 on 24 Aug 2022
  • Changed by Imke Tammen2 on 25 Aug 2022