OMIA:002592-9915 : Theileriosis, susceptibility/resistance to in Bos indicus (indicine cattle (zebu))

In other species: taurine cattle

Categories: Immune system phene

Single-gene trait/disorder: no

Mode of inheritance: Multifactorial

Disease-related: yes

Key variant known: no

Species-specific name: Tolerance to Theileria parva infection, East Coast fever

Inheritance: Wragg et al. (2022) "report on the genetic analysis of a cohort of Bos indicus (Boran) cattle demonstrating heritable tolerance to infection with T. parva (h2 = 0.65, s.e. 0.57)."

Mapping: Wragg et al. (2022): "Through a linkage analysis we identify a 6 Mb genomic region on bovine chromosome 15 that is significantly associated with survival outcome following T. parva exposure. Testing this locus in an independent cohort of animals replicates this association with survival following T. parva infection."

Markers: Wragg et al. (2022): "A stop gained variant in a paralogue of the FAF1 gene in this region was found to be highly associated with survival across both related and unrelated animals ... raising the promise of marker-assisted selection for cattle that are less susceptible to infection by T. parva."

Breeds: Boran (Cattle) (VBO_0000156), Kedah-Kelantan, Malaysia (Cattle) (VBO_0005124).
Breeds in which the phene or likely causal variants have been documented. If a likely causal variant has been documented, see variant-specific breed information in the variant table. (Breed information may be incomplete).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
FAF1 Bos indicus 3 NC_091762.1 (95606808..96104520) FAF1 Ensembl, NCBI gene

Contact us

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002592-9915: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2025 Kalaiyarasi, K., Elayadeth-Meethal, M. :
Characterization and identification of novel polymorphisms in the OR51H1 gene associated with resistance/tolerance to natural Theileria infection in Vechur (Bos indicus) and crossbred (B. taurus × B. indicus) cattle in a Theileria-endemic region. Vet Parasitol Reg Stud Reports 60:S2405-9390(25)00050-4:101242, 2025. Pubmed reference: 40280682. DOI: 10.1016/j.vprsr.2025.101242.
2024 Agina, O.A., Shaari, M.R., Isa, N.M.M., Ajat, M., Zamri-Saad, M., Hamzah, H. :
Identification of novel bovine leukocyte antigen alleles and association of BoLA-DRB3.2*020:02:01 with resistance to Theileria orientalis infection in crossbred Kedah-Kelantan cattle: a pilot study. Trop Anim Health Prod 56:277, 2024. Pubmed reference: 39316238. DOI: 10.1007/s11250-024-04138-0.
2022 Wragg, D., Cook, E.A.J., Latré de Laté, P., Sitt, T., Hemmink, J.D., Chepkwony, M.C., Njeru, R., Poole, E.J., Powell, J., Paxton, E.A., Callaby, R., Talenti, A., Miyunga, A.A., Ndambuki, G., Mwaura, S., Auty, H., Matika, O., Hassan, M., Marshall, K., Connelley, T., Morrison, L.J., Bronsvoort, B.M.D., Morrison, W.I., Toye, P.G., Prendergast, J.G.D. :
A locus conferring tolerance to Theileria infection in African cattle. PLoS Genet 18:e1010099, 2022. Pubmed reference: 35446841. DOI: 10.1371/journal.pgen.1010099.

Edit History


  • Created by Imke Tammen2 on 15 Nov 2022
  • Changed by Imke Tammen2 on 15 Nov 2022
  • Changed by Imke Tammen2 on 23 Jan 2024
  • Changed by Imke Tammen2 on 26 Sep 2024