OMIA:002592-9915 : Theileriosis, susceptibility/resistance to in Bos indicus (indicine cattle (zebu))

In other species: taurine cattle

Categories: Immune system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Species-specific name: Tolerance to Theileria parva infection, East Coast fever

Inheritance: Wragg et al. (2022) "report on the genetic analysis of a cohort of Bos indicus (Boran) cattle demonstrating heritable tolerance to infection with T. parva (h2 = 0.65, s.e. 0.57)."

Mapping: Wragg et al. (2022): "Through a linkage analysis we identify a 6 Mb genomic region on bovine chromosome 15 that is significantly associated with survival outcome following T. parva exposure. Testing this locus in an independent cohort of animals replicates this association with survival following T. parva infection."

Markers: Wragg et al. (2022): "A stop gained variant in a paralogue of the FAF1 gene in this region was found to be highly associated with survival across both related and unrelated animals ... raising the promise of marker-assisted selection for cattle that are less susceptible to infection by T. parva."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: Boran (Cattle) (VBO_0000156).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
FAF1 Bos indicus 3 NC_032652.1 (102196185..102640489) FAF1 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002592-9915: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2022 Wragg, D., Cook, E.A.J., Latré de Laté, P., Sitt, T., Hemmink, J.D., Chepkwony, M.C., Njeru, R., Poole, E.J., Powell, J., Paxton, E.A., Callaby, R., Talenti, A., Miyunga, A.A., Ndambuki, G., Mwaura, S., Auty, H., Matika, O., Hassan, M., Marshall, K., Connelley, T., Morrison, L.J., Bronsvoort, B.M.D., Morrison, W.I., Toye, P.G., Prendergast, J.G.D. :
A locus conferring tolerance to Theileria infection in African cattle. PLoS Genet 18:e1010099, 2022. Pubmed reference: 35446841. DOI: 10.1371/journal.pgen.1010099.

Edit History

  • Created by Imke Tammen2 on 15 Nov 2022
  • Changed by Imke Tammen2 on 15 Nov 2022
  • Changed by Imke Tammen2 on 23 Jan 2024