OMIA:002601-9940 : Type I interferon receptor deficiency in Ovis aries (sheep) |
Categories: Immune system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 602376 (gene) , 616669 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: unknown
Key variant known: yes
Year key variant first reported: 2022
Species-specific description: Davies et al. (2022): "One or both chains of the sheep IFNAR were disrupted in fetal fibroblast lines using CRISPR/Cas9 and 12 lambs were produced by somatic cell nuclear transfer (SCNT). ... Although many lambs have died from SCNT related problems or infections, one fertile IFNAR2 -/- ram lived to over 4 years of age, remained healthy, and produced more than 80 offspring. Interestingly, ZIKV infection studies failed to demonstrate a high level of susceptibility. Presumably, these sheep compensated for a lack of type I IFN signaling using the type II, IFN-gamma and type III, IFN-lambda pathways. ... A breeding herd of 32 IFNAR2 +/- ewes, which are fertile, has been developed for production of IFNAR2 -/- sheep for both infection and reproduction studies." This study involves genetically modified organisms (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| IFNAR2 | interferon (alpha, beta and omega) receptor 2 | Ovis aries | 1 | NC_056054.1 (123014718..122979204) | IFNAR2 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:002601-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2022 | Davies, C.J., Fan, Z., Morgado, K.P., Liu, Y., Regouski, M., Meng, Q., Thomas, A.J., Yun, S.I., Song, B.H., Frank, J.C., Perisse, I.V., Van Wettere, A., Lee, Y.M., Polejaeva, I.A. : |
| Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling. Front Genet 13:986316, 2022. Pubmed reference: 36246651 . DOI: 10.3389/fgene.2022.986316. |
Edit History
- Created by Imke Tammen2 on 24 Nov 2022
- Changed by Imke Tammen2 on 24 Nov 2022