OMIA:002601-9940 : Type I interferon receptor deficiency in Ovis aries (sheep)

Categories: Immune system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 602376 (gene) , 616669 (trait)

Mendelian trait/disorder: yes

Considered a defect: unknown

Key variant known: yes

Year key variant first reported: 2022

Species-specific description: Davies et al. (2022): "One or both chains of the sheep IFNAR were disrupted in fetal fibroblast lines using CRISPR/Cas9 and 12 lambs were produced by somatic cell nuclear transfer (SCNT). ... Although many lambs have died from SCNT related problems or infections, one fertile IFNAR2 -/- ram lived to over 4 years of age, remained healthy, and produced more than 80 offspring. Interestingly, ZIKV infection studies failed to demonstrate a high level of susceptibility. Presumably, these sheep compensated for a lack of type I IFN signaling using the type II, IFN-gamma and type III, IFN-lambda pathways. ... A breeding herd of 32 IFNAR2 +/- ewes, which are fertile, has been developed for production of IFNAR2 -/- sheep for both infection and reproduction studies." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
IFNAR2 interferon (alpha, beta and omega) receptor 2 Ovis aries 1 NC_056054.1 (123014718..122979204) IFNAR2 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002601-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2022 Davies, C.J., Fan, Z., Morgado, K.P., Liu, Y., Regouski, M., Meng, Q., Thomas, A.J., Yun, S.I., Song, B.H., Frank, J.C., Perisse, I.V., Van Wettere, A., Lee, Y.M., Polejaeva, I.A. :
Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling. Front Genet 13:986316, 2022. Pubmed reference: 36246651. DOI: 10.3389/fgene.2022.986316.

Edit History

  • Created by Imke Tammen2 on 24 Nov 2022
  • Changed by Imke Tammen2 on 24 Nov 2022
  • Changed by Imke Tammen2 on 18 Dec 2023