OMIA:002660-9823 : Resistance/susceptibility to avian influenza virus in Sus scrofa (pig) |
In other species: Mallard , chicken
Categories: Immune system phene
Mendelian trait/disorder: unknown
Disease-related: yes
Molecular basis: Kwon et al. (2024) "aimed to determine the effects of TMPRSS2 on the replication of pandemic H1N1 and H3N2 subtype IAVs in the natural host, the pig. The use of the CRISPR/Cas 9 system led to the establishment of homozygous gene edited (GE) TMPRSS2 knockout (KO) pigs. Delayed IAV replication was demonstrated in primary respiratory cells of KO pigs in vitro. IAV infection in vivo resulted in significant reduction of virus shedding in the upper respiratory tract, and lower virus titers and pathological lesions in the lower respiratory tract of TMPRSS2 KO pigs as compared to WT pigs." This study involves genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| TMPRSS2 | transmembrane serine protease 2 | Sus scrofa | 13 | NC_010455.5 (204905411..204874759) | TMPRSS2 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002660-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Kwon, T., Artiaga, B.L., McDowell, C.D., Whitworth, K.M., Wells, K.D., Prather, R.S., Delhon, G., Cigan, M., White, S.N., Retallick, J., Gaudreault, N.N., Morozov, I., Richt, J.A. : |
| Gene editing of pigs to control influenza A virus infections. bioRxiv , 2024. Pubmed reference: 38293027. DOI: 10.1101/2024.01.15.575771. | |
| Kwon, T., Artiaga, B.L., McDowell, C.D., Whitworth, K.M., Wells, K.D., Prather, R.S., Delhon, G., Cigan, M., White, S.N., Retallick, J., Gaudreault, N.N., Morozov, I., Richt, J.A. : | |
| Gene editing of pigs to control influenza A virus infections. Emerg Microbes Infect 13:2387449, 2024. Pubmed reference: 39083026. DOI: 10.1080/22221751.2024.2387449. | |
| 2023 | Ciacci Zanella, G., Snyder, C.A., Arruda, B.L., Whitworth, K., Green, E., Poonooru, R.R., Telugu, B.P., Baker, A.L. : |
| Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with influenza A virus. Front Genome Ed 5:1320180, 2023. Pubmed reference: 38883409. DOI: 10.3389/fgeed.2023.1320180. |
Edit History
- Created by Imke Tammen2 on 03 May 2024
- Changed by Imke Tammen2 on 03 May 2024