OMIA:002699-9913 : Bovine viral diarrhea virus, resistance/susceptibility to in Bos taurus (taurine cattle)

Categories: Immune system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 120920 (gene)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Workman et al. (2023) "used CRISPR-mediated homology-directed repair and somatic cell nuclear transfer to produce a live calf with a six amino acid substitution in the BVDV binding domain of bovine CD46. The result was a gene-edited calf with dramatically reduced susceptibility to infection as measured by reduced clinical signs and the lack of viral infection in white blood cells. The edited calf has no off-target edits and appears normal and healthy at 20 months of age without obvious adverse effects from the on-target edit." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
CD46 CD46 molecule Bos taurus 16 NC_037343.1 (75621087..75582021) CD46 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002699-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Workman, A.M., Heaton, M.P., Vander Ley, B.L., Webster, D.A., Sherry, L., Bostrom, J.R., Larson, S., Kalbfleisch, T.S., Harhay, G.P., Jobman, E.E., Carlson, D.F., Sonstegard, T.S. :
First gene-edited calf with reduced susceptibility to a major viral pathogen. PNAS Nexus 2:pgad125, 2023. Pubmed reference: 37181049. DOI: 10.1093/pnasnexus/pgad125.
2022 Leveringhaus, E., Cagatay, G.N., Hardt, J., Becher, P., Postel, A. :
Different impact of bovine complement regulatory protein 46 (CD46 bov) as a cellular receptor for members of the species Pestivirus H and Pestivirus G. Emerg Microbes Infect 11:60-72, 2022. Pubmed reference: 34839792. DOI: 10.1080/22221751.2021.2011620.
2021 Chen, H.W., Huber, V., Szakmary-Braendle, K., Seitz, K., Moetz, M., Ruemenapf, T., Riedel, C. :
Viral traits and cellular knock-out genotype affect dependence of BVDV on bovine CD46. Pathogens 10, 2021. Pubmed reference: 34959575. DOI: 10.3390/pathogens10121620.
2020 Szillat, K.P., Koethe, S., Wernike, K., Höper, D., Beer, M. :
A CRISPR/Cas9 generated bovine CD46-knockout cell line-A tool to elucidate the adaptability of bovine viral diarrhea viruses (BVDV). Viruses 12, 2020. Pubmed reference: 32781607. DOI: 10.3390/v12080859.
2006 Krey, T., Himmelreich, A., Heimann, M., Menge, C., Thiel, H.J., Maurer, K., Rümenapf, T. :
Function of bovine CD46 as a cellular receptor for bovine viral diarrhea virus is determined by complement control protein 1. J Virol 80:3912-22, 2006. Pubmed reference: 16571808. DOI: 10.1128/JVI.80.8.3912-3922.2006.
2004 Maurer, K., Krey, T., Moennig, V., Thiel, H.J., Rümenapf, T. :
CD46 is a cellular receptor for bovine viral diarrhea virus. J Virol 78:1792-9, 2004. Pubmed reference: 14747544. DOI: 10.1128/jvi.78.4.1792-1799.2004.

Edit History

  • Created by Imke Tammen2 on 16 May 2023
  • Changed by Imke Tammen2 on 16 May 2023
  • Changed by Imke Tammen2 on 18 Dec 2023