Categories: Cellular phene

Single-gene trait/disorder: unknown

Disease-related: no

Cross-species summary: Information relating to the use of genetically engineered animals to produce proteins for pharmaceutical use (e.g. vaccines, antibodies, hormones) is listed here.

Molecular basis: Park et al. (2023) "generated genome-edited chickens that synthesize human IgG1 Fc in the liver and secrete α-2,6 sialylated and low-fucosylated human IgG1 Fc (rhIgG1 Fc) into serum and egg yolk." This study involves genetically modified organisms (GMO).
Kawabe et al. (2026) "report a compact synthetic promoter–feedback circuit that enables enhanced, oviduct-restricted transgene expression in chickens. ... As a functional demonstration, chickens expressing transforming growth factor beta 1 (TGF-β1) specifically in egg white were generated." 

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing