OMIA:002773-9031 : T cell deficiency in Gallus gallus (chicken)

Categories: Immune system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2023

Species-specific description: von Heyl et al. (2023): "CRISPR/Cas9 was used to knockout either [alpha/beta] or [gamma/delta] T cells in chickens in order to further analyze the adaptive immune response in poultry. While chickens lacking [gamma/delta] T cells showed no obvious phenotype beside missing [gamma/delta] T cells, birds lacking [alpha/beta] T cells revealed a severe immunophenotype." This study involves genetically modified organisms (GMO).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002773-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2023 von Heyl, T., Klinger, R., Aumann, D., Zenner, C., Alhussien, M., Schlickenrieder, A., Lengyel, K., Vikkula, H.K., Mittermair, T., Sid, H., Schusser, B. :
Loss of αβ but not γδ T cells in chickens causes a severe phenotype. Eur J Immunol :e2350503, 2023. Pubmed reference: 37735713 . DOI: 10.1002/eji.202350503.

Edit History

  • Created by Imke Tammen2 on 23 Sep 2023