OMIA:002773-9031 : T cell deficiency in Gallus gallus (chicken) |
Categories: Immune system phene
Single-gene trait/disorder: yes
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2023
Species-specific description: von Heyl et al. (2023): "CRISPR/Cas9 was used to knockout either [alpha/beta] or [gamma/delta] T cells in chickens in order to further analyze the adaptive immune response in poultry. While chickens lacking [gamma/delta] T cells showed no obvious phenotype beside missing [gamma/delta] T cells, birds lacking [alpha/beta] T cells revealed a severe immunophenotype." This study involves genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002773-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
2023 | von Heyl, T., Klinger, R., Aumann, D., Zenner, C., Alhussien, M., Schlickenrieder, A., Lengyel, K., Vikkula, H.K., Mittermair, T., Sid, H., Schusser, B. : |
Loss of αβ but not γδ T cells in chickens causes a severe phenotype. Eur J Immunol 53:e2350503, 2023. Pubmed reference: 37735713. DOI: 10.1002/eji.202350503. |
Edit History
- Created by Imke Tammen2 on 23 Sep 2023
- Changed by Imke Tammen2 on 18 Dec 2023