OMIA:002773-9031 : T cell deficiency in Gallus gallus (chicken)
Categories: Immune system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: yes
Year key variant first reported: 2023
Species-specific description: von Heyl et al. (2023): "CRISPR/Cas9 was used to knockout either [alpha/beta] or [gamma/delta] T cells in chickens in order to further analyze the adaptive immune response in poultry. While chickens lacking [gamma/delta] T cells showed no obvious phenotype beside missing [gamma/delta] T cells, birds lacking [alpha/beta] T cells revealed a severe immunophenotype." This study involves genetically modified organisms (GMO).
Cite this entry
|2023||von Heyl, T., Klinger, R., Aumann, D., Zenner, C., Alhussien, M., Schlickenrieder, A., Lengyel, K., Vikkula, H.K., Mittermair, T., Sid, H., Schusser, B. :|
|Loss of αβ but not γδ T cells in chickens causes a severe phenotype. Eur J Immunol :e2350503, 2023. Pubmed reference: 37735713 . DOI: 10.1002/eji.202350503.|
- Created by Imke Tammen2 on 23 Sep 2023