Gene TP53 : tumor protein p53 in Sus scrofa |
See the equivalent entry at NCBI |
In other species:
dog
,
crab-eating macaque
,
golden hamster
Symbol:
TP53
Synonyms: P53
Description:
tumor protein p53
Type of gene:
protein-coding
Comment:
Using transgenesis of mesenchymal stem cells, followed by somatic cell nuclear transfer, Leuchs et al. (2012) created cloned pigs heterozygous for "a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53(R175H) and mouse Trp53(R172H), that can be activated by Cre recombination . . . which represents the first inactivation and mutation of the gatekeeper tumor suppressor gene TP53 in a non-rodent mammal".
NCBI gene id:
397276
Other designations:
cellular tumor antigen p53|tumor suppressor p53
Links:
Homologene
, Ensembl
Genomic location:
12:52953786..52939643 [Chromosome accession
NC_010454.4]
Related phenes:
OMIA:001990-9823 : Cancer, TP53-related in
Sus scrofa
Reference
| 2012 | Leuchs, S., Saalfrank, A., Merkl, C., Flisikowska, T., Edlinger, M., Durkovic, M., Rezaei, N., Kurome, M., Zakhartchenko, V., Kessler, B., Flisikowski, K., Kind, A., Wolf, E., Schnieke, A. : |
| Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. PLoS One 7:e43323, 2012. Pubmed reference: 23071491. DOI: 10.1371/journal.pone.0043323. |
Edit History
- Changed by Frank Nicholas on 04 May 2013