OMIA 000038-59729 : Amyloidosis, AA in Taeniopygia guttata

In other species: chicken , bats , white-tufted-ear marmoset , dog , red fox , domestic cat , Sumatran tiger , pig , cattle , goat , sheep , dolphinfishes , cheetah , island gray fox

Possibly relevant human trait(s) and/or gene(s) (MIM number): 134610

Mendelian trait/disorder: unknown

Considered a defect: yes

Molecular basis: By sequencing a comparative candidate gene (SAA2), Shientag et al. (2019) identified an "R52L substitution [that] occurred in 2 otherwise healthy birds with hepatic AA amyloidosis, supporting the idea that this change is pathogenic".

Reference


2019 Shientag, L.J., Cabrera, O.A., Pazour, G.J. :
Allelic Diversity in the Serum Amyloid A2 Gene and Amyloid A Amyloidosis in a Breeding Colony of Zebra Finches (Taeniopygia guttata). Comp Med :, 2019. Pubmed reference: 31462347. DOI: 10.30802/AALAS-CM-18-000139.

Edit History


  • Created by Frank Nicholas on 05 Sep 2019
  • Changed by Frank Nicholas on 05 Sep 2019