OMIA:000038-9615 : Amyloidosis, AA in Canis lupus familiaris (dog)

In other species: chicken , bats , white-tufted-ear marmoset , red fox , domestic cat , Sumatran tiger , bottlenosed dolphin , pig , taurine cattle , goat , sheep , cheetah , northern tree shrew , Japanese squirrel , zebra finch , island gray fox

Categories: Homeostasis / metabolism phene

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: “Amyloid is the term for a misfolded protein that accumulates as insoluble fibrils in various organ and tissue sites to result in a clinical syndrome known as amyloidosis. The chemical diversity of amyloid and amyloidosis has been evident since the mid-1970s and the number of known human amyloid proteins has steadily increased from two at that time to 36 at Amyloid deposition, either hereditary or acquired, is seldom benign and, when clinical symptoms appear, they are frequently life-threatening. The best way to distinguish the different forms of amyloid is by chemical characterization. (Immuno-)histochemical typing of amyloid is readily available … . [A] second descriptor is whether the patient’s amyloid is limited (localized) or throughout the whole body (systemic). Each amyloid syndrome should be named according to the Nomenclature Guidelines of the ISA. Most of the distinct amyloidosis syndromes are named after the fibril forming protein, e.g. AL (amyloid derived from immunoglobulin light chain) amyloidosis (localized or systemic), AA amyloidosis (amyloid derived from SAA – serum amyloid A protein) … .” (International Society of Amyloidosis) Sipe et al., 2016: “The terms “hereditary amyloidosis” and “familial amyloidosis” refer to different entities. The term “hereditary amyloidosis” should be used when there is a mutation in the fibril protein gene itself, e.g. ATTR, ALys or AFib. The term “familial amyloidosis” should be used when the syndrome occurs in a familial setting due to mutations in genes expressing non-amyloid proteins, e.g. AA amyloidosis.”

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:000038-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2016 Sipe, J.D., Benson, M.D., Buxbaum, J.N., Ikeda, S.I., Merlini, G., Saraiva, M.J., Westermark, P. :
Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines. Amyloid 23:209-213, 2016. Pubmed reference: 27884064. DOI: 10.1080/13506129.2016.1257986.
2013 Olsson, M., Tintle, L., Kierczak, M., Perloski, M., Tonomura, N., Lundquist, A., Murén, E., Fels, M., Tengvall, K., Pielberg, G., Dufaure de Citres, C., Dorso, L., Abadie, J., Hanson, J., Thomas, A., Leegwater, P., Hedhammar, A., Lindblad-Toh, K., Meadows, J.R. :
Thorough investigation of a canine autoinflammatory disease (AID) confirms one main risk locus and suggests a modifier locus for amyloidosis. PLoS One 8:e75242, 2013. Pubmed reference: 24130694. DOI: 10.1371/journal.pone.0075242.
2012 Segev, G., Cowgill, L.D., Jessen, S., Berkowitz, A., Mohr, C.F., Aroch, I. :
Renal amyloidosis in dogs: A retrospective study of 91 cases with comparison of the disease between Shar-Pei and Non-Shar-Pei dogs. J Vet Intern Med , 2012. Pubmed reference: 22268374. DOI: 10.1111/j.1939-1676.2011.00878.x.
1996 Gruys, E. :
Inflammatory syndrome of footpads in puppies and AA-amyloidosis Veterinary Record 138:264, 1996. Pubmed reference: 8734514.
1995 Johnson, K.H., Sletten, K., Hayden, D.W., Obrien, T.D., Rossow, K.D., Westermark, P. :
AA amyloidosis in Chinese Shar-pei dogs: Immunohistochemical and amino acid sequence analyses Amyloid - International Journal of Experimental and Clinical Investigation 2:92-99, 1995.
Johnson, K.H., Sletten, K., Hayden, D.W., Obrien, T.D., Rossow, K.D., Westermark, P. :
AA amyloidosis in Chinese Shar-Pei dogs - immunohistochemical and amino acid sequence analyses (vol 2, pg 92, 1995) Amyloid-International Journal of Experimental & Clinical Investigation 2:293, 1995.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 23 Apr 2021