OMIA:000061-9689 : Arnold-Chiari malformation in Panthera leo (lion)

In other species: tiger , taurine cattle , bobcat

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 207950 (trait) , 118420 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Viere et al. (2021): “Chiari-like malformation have been reported in lions, in association with hypovitaminosis A. A genetic component is suspected in the development of this disease, causing a reduced ability to absorb vitamin A.” (Edited by Natalia Denisse Ramos Reyes 7/11/2022)

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:000061-9689: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Viere, A.R., Cushing, A.C., Ramsay, E.C., Craig, L.E. :
A retrospective study of brain lesions in captive nondomestic felids. J Zoo Wildl Med 52:918-925, 2021. Pubmed reference: 34687508. DOI: 10.1638/2021-0016.
2010 Scaglione, F.E., Schröder, C., Degiorgi, G., Zeira, O., Bollo, E. :
Cranial malformations in related white lions (Panthera leo krugeri). Vet Pathol 47:1095-9, 2010. Pubmed reference: 20826844. DOI: 10.1177/0300985810382518.
2008 McCain, S., Souza, M., Ramsay, E., Schumacher, J., Hecht, S., Thomas, W. :
Diagnosis and surgical treatment of a Chiari I-like malformation in an African lion (Panthera leo). J Zoo Wildl Med 39:421-7, 2008. Pubmed reference: 18817006.
2000 [No authors listed] :
Letter to the editor concerning Arnold-Chiari malformation in a captive African lion cub. J Wildl Dis 36:190-1, 2000. Pubmed reference: 10682766.
1999 Chandra, A.M., Papendick, R.E., Schumacher, J., Homer, B.L., Wollenman, P. :
Cerebellar herniation in captive lions (Panthera leo). J Vet Diagn Invest 11:465-8, 1999. Pubmed reference: 12968763. DOI: 10.1177/104063879901100514.
1998 Shamir, MH., Horowitz, IH., Yakobson, B., Ofri, R. :
Arnold-Chiari malformation in a captive African lion cub. J Wildl Dis 34:661-6, 1998. Pubmed reference: 9706583.

Edit History

  • Created by Frank Nicholas on 22 Mar 2011
  • Changed by Imke Tammen2 on 07 Nov 2022