OMIA 000080-10036 : Atherosclerosis in Mesocricetus auratus

In other species: rock pigeon , dog , domestic cat , pig , Japanese quail

Possibly relevant human trait(s) and/or gene(s) (MIM number): 108725 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A common form of arteriosclerosis in which deposits of yellowing plaques (atheromas) containing cholesterol and other lipid material are formed within the arteries.

Species-specific description: Hamsters have been used as models for dyslipidemia and atherosclerosis for many decades. Xian et al. (2022) summarise their research relating to several CRISPR/Cas9 genetically engineered hamster models for dyslipidemia, created by targeting low density lipoprotein receptor (LDLR) (Wu et al., 2019), lecithin cholesterol acyl transferase (LCAT) (Dong et al., 2018), ApoC2 (Gao et al., 2020), ApoC3 (Guo et al., 2020), and adenosine triphosphate-binding cassette transporter A1 (ABCA1) (Wei et al., 2019) genes. This entry includes references to studies involving gene edited organisms (GMO).

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2022 Xian, X., Wang, Y., Liu, G. :
Genetically engineered hamster models of dyslipidemia and atherosclerosis. Methods Mol Biol 2419:433-459, 2022. Pubmed reference: 35237980. DOI: 10.1007/978-1-0716-1924-7_26.
2020 Gao, M., Yang, C., Wang, X., Guo, M., Yang, L., Gao, S., Zhang, X., Ruan, G., Li, X., Tian, W., Lu, G., Dong, X., Ma, S., Li, W., Wang, Y., Zhu, H., He, J., Yang, H., Liu, G., Xian, X. :
ApoC2 deficiency elicits severe hypertriglyceridemia and spontaneous atherosclerosis: A rodent model rescued from neonatal death. Metabolism 109:154296, 2020. Pubmed reference: 32562799. DOI: 10.1016/j.metabol.2020.154296.
Guo, M., Xu, Y., Dong, Z., Zhou, Z., Cong, N., Gao, M., Huang, W., Wang, Y., Liu, G., Xian, X. :
Inactivation of ApoC3 by CRISPR/Cas9 protects against atherosclerosis in hamsters. Circ Res 127:1456-1458, 2020. Pubmed reference: 32951534. DOI: 10.1161/CIRCRESAHA.120.317686.
2019 Wei, L., Shi, H., Lin, X., Zhang, X., Wang, Y., Liu, G., Xian, X. :
Impact of cholesterol on ischemic stroke in different human-like hamster models: A new animal model for ischemic stroke study. Cells 8:, 2019. Pubmed reference: 31487778. DOI: 10.3390/cells8091028.
Wu, Y., Xu, M.J., Cao, Z., Yang, C., Wang, J., Wang, B., Liu, J., Wang, Y., Xian, X., Zhang, F., Liu, G., Chen, X. :
Heterozygous Ldlr-deficient hamster as a model to evaluate the efficacy of PCSK9 antibody in hyperlipidemia and atherosclerosis. Int J Mol Sci 20:, 2019. Pubmed reference: 31779098. DOI: 10.3390/ijms20235936.
2018 Dong, Z., Shi, H., Zhao, M., Zhang, X., Huang, W., Wang, Y., Zheng, L., Xian, X., Liu, G. :
Loss of LCAT activity in the golden Syrian hamster elicits pro-atherogenic dyslipidemia and enhanced atherosclerosis. Metabolism 83:245-255, 2018. Pubmed reference: 29526535. DOI: 10.1016/j.metabol.2018.03.003.
1987 Nistor, A., Bulla, A., Filip, D.A., Radu, A. :
The hyperlipidemic hamster as a model of experimental atherosclerosis. Atherosclerosis 68:159-73, 1987. Pubmed reference: 3689479. DOI: 10.1016/0021-9150(87)90106-7.
1950 Altschul, R. :
Experimental cholesterol arteriosclerosis. II. Changes produced in golden hamsters and in guinea pigs. Am Heart J 40:401-9, 1950. Pubmed reference: 14770982. DOI: 10.1016/0002-8703(50)90323-1.

Edit History


  • Created by Imke Tammen2 on 17 Sep 2022
  • Changed by Imke Tammen2 on 17 Sep 2022