OMIA:000080-8932 : Atherosclerosis in Columba livia (rock pigeon)

In other species: dog , domestic cat , pig , golden hamster , Japanese quail

Categories: Cardiovascular system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 108725 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: no

Cross-species summary: A common form of arteriosclerosis in which deposits of yellowing plaques (atheromas) containing cholesterol and other lipid material are formed within the arteries.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:000080-8932: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Zhang, Y., Fatima, M., Hou, S., Bai, L., Zhao, S., Liu, E. :
Research methods for animal models of atherosclerosis (Review). Mol Med Rep 24:871, 2021. Pubmed reference: 34713295. DOI: 10.3892/mmr.2021.12511.
2014 Anderson, J.L., Smith, S.C., Taylor, R.L. :
The pigeon (Columba livia) model of spontaneous atherosclerosis. Poult Sci , 2014. Pubmed reference: 25214557. DOI: 10.3382/ps.2014-04280.
2013 Anderson, J.L., Ashwell, C.M., Smith, S.C., Shine, R., Smith, E.C., Taylor, R.L. :
Atherosclerosis-susceptible and atherosclerosis-resistant pigeon aortic cells express different genes in vivo. Poult Sci 92:2668-80, 2013. Pubmed reference: 24046414. DOI: 10.3382/ps.2013-03306.
2001 Smith, S.C., Smith, E.C., Taylor, R.L. :
Susceptibility to spontaneous atherosclerosis in pigeons: An autosomal recessive trait Journal of Heredity 92:439-442, 2001. Pubmed reference: 11773255.
1992 Schwenke, D.C., St Clair, R.W. :
Accumulation of 125I-tyramine cellobiose-labeled low density lipoprotein is greater in the atherosclerosis-susceptible region of White Carneau pigeon aorta and further enhanced once atherosclerotic lesions develop. Arterioscler Thromb 12:446-60, 1992. Pubmed reference: 1558836.
1991 Boyd, C.D., Song, J.Y., Kniep, A.C., Park, H.S., Fastnacht, C., Smith, E.C., Smith, S.C. :
A restriction fragment length polymorphism in the pigeon pro alpha 2(1) collagen gene: lack of an allelic association with an atherogenic phenotype in pigeons genetically susceptible to the development of spontaneous atherosclerosis. Connect Tissue Res 26:187-97, 1991. Pubmed reference: 1685110.
1986 St Clair, R.W., Leight, M.A., Barakat, H.A. :
Metabolism of low density lipoproteins by pigeon skin fibroblasts and aortic smooth muscle cells. Comparison of cells from atherosclerosis-susceptible and atherosclerosis-resistant pigeons. Arteriosclerosis 6:170-7, 1986. Pubmed reference: 3954671.
1984 Hogg, S.I., Cryer, A. :
Analysis and lipoprotein lipase activation capacity of plasma lipoproteins isolated from atherosclerosis-susceptible White Carneau pigeon and atherosclerosis-resistant Show Racer pigeon. Comp Biochem Physiol B 79:251-4, 1984. Pubmed reference: 6509917.
1981 Fronek, K., Alexander, N. :
Genetic difference in the sympathetic nervous activity and susceptibility to atherosclerosis in pigeon. Atherosclerosis 39:25-33, 1981. Pubmed reference: 7247988.
1980 Gerritsen, M.E., Printz, M.P. :
Prostaglandin E2 synthesis in pigeon aorta: comparison of atherosclerosis-resistant (Show Racer) and atherosclerosis-prone (White Carneau) breeds. Artery 8:56-62, 1980. Pubmed reference: 7425866.
Hajjar, D.P., Smith, S.C. :
Focal differences in bioenergetic metabolism of atherosclerosis-susceptible and -resistant pigeon aortas. Atherosclerosis 36:209-22, 1980. Pubmed reference: 7406950.
1979 Wagner, W.D. :
Aortic glycopeptide sialic acid, hexose and hexosamine in a genetically selected (WC-2) strain of atherosclerosis-susceptible pigeon. Atherosclerosis 34:1-11, 1979. Pubmed reference: 497039.
1977 Curwen, K.D., Smith, S.C. :
Heparitin sulfates (heparan sulfates) of atherosclerosis-susceptible and atherosclerosis-resistant pigeon aortas. Atherosclerosis 27:113-7, 1977. Pubmed reference: 140692.
1976 Cramer, E.B., Smith, S.C. :
Yolk lipids of developing atherosclerosis susceptible White Carneau and atherosclerosis resistant Show Racer pigeon embryos. J Nutr 106:627-30, 1976. Pubmed reference: 944245.
Lewis, J.C., Fuster, V., Kottke, B.A. :
Thrombocytes in atherosclerosis-resistant and atherosclerosis-susceptible breeds of pigeon: a comparative ultrastructural study. Exp Mol Pathol 25:332-43, 1976. Pubmed reference: 1001405.
1973 Wagner, W.D., Clarkson, T.B., Feldner, M.A., Prichard, R.W. :
The development of pigeon strains with selected atherosclerosis characteristics. Exp Mol Pathol 19:304-19, 1973. Pubmed reference: 4763632.
1971 Subbiah, M.T., Kottke, B.A., Carlo, I.A., Weaver, K.M. :
Bile salts of spontaneously atherosclerosis-susceptible white Carneau pigeon. Steroids 17:509-19, 1971. Pubmed reference: 5136065.
1970 Subbiah, M.T., Kottke, B.A., Carlo, I.A. :
Experimental studies in the spontaneous-atherosclerosis-susceptible White Carneau pigeon: nature of biliary and fecal neutral steroids. Mayo Clin Proc 45:729-37, 1970. Pubmed reference: 5529530.
1961 Clarkson, T.B., Lofland, H.B. :
Effects of cholesterol-fat diets on pigeons susceptible and resistant to atherosclerosis Circulation Research 9:106-109, 1961. Pubmed reference: 13693917.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 05 Aug 2013