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OMIA 000080-9823 : Atherosclerosis in Sus scrofa

In other species: rock pigeon , dog , Japanese quail

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 108725 (trait) , 209010 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A common form of arteriosclerosis in which deposits of yellowing plaques (atheromas) containing cholesterol and other lipid material are formed within the arteries.

Species-specific description: A strain of pig that spontaneously develops atherosclerosis has been developed by selection (Skold and Getty, 1961; Gal et al., 1990), and is used as an animal model for medical studies of the same disease in humans.

Inheritance: familial

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1996 Ali, M.N., Mazur, W., Kleiman, N.S., Rodgers, G.P., Abukhalil, J.M., French, B.A., Raizner, A.E. :
Inhibition of coronary restenosis by antithrombin iii in atherosclerotic swine Coronary Artery Disease 7:851-861, 1996. Pubmed reference: 8993944.
1990 Armstrong, M.L., Heistad, D.D. :
Animal Models of Atherosclerosis Atherosclerosis 85:15-23, 1990. Pubmed reference: 2282105.
Gal, D., Rongione, A.J., Slovenkai, G.A., Dejesus, S.T., Lucas, A., Fields, C.D., Isner, J.M. :
Atherosclerotic Yucatan Microswine - An Animal Model with High- Grade, Fibrocalcific, Nonfatty Lesions Suitable for Testing Catheter-Based Interventions American Heart Journal 119:291-300, 1990. Pubmed reference: 2301218.
Rapacz, J., Hasler-Rapacz, J. :
The Pig and Its Plasma Lipoprotein Polymorphism in Studies of Atherosclerosis Journal of Animal Breeding and Genetics-Zeitschrift Fur Tierzuchtung und Zuchtungsbiologie :131-146, 1990.
1989 Rapacz, J., Hasler-Rapacz, J. :
Animal Models - The Pig Genetic Factors in Atherosclerosis : Approaches and Model Systems 12:139-169, 1989.
1986 Rapcz, J., Hasler-Rapacz, J., Taylor, K.M., Checovich, W.J., Attie, A.D. :
Lipoprotein mutations in pigs are associated with elevated plasma cholesterol and atherosclerosis Science 234:1573-1577, 1986. Pubmed reference: 3787263.
1963 Downie, H.G., Mustard, J.F., Rowsell, H.C. :
Swine atherosclerosis: the relationships of lipids and blood coagulation to its development Annals of the New York Academy of Sciences 104:539-562, 1963.
1961 Skold, B.H., Getty, R. :
Spontaneous atherosclerosis of swine Journal of the American Veterinary Medical Association 139:655-660, 1961.

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  • Created by Frank Nicholas on 06 Sep 2005