In other species: chicken , grivet , crab-eating macaque , dog , giant panda , domestic ferret , domestic cat , lion , ass (donkey) , horse , sheep , rabbit , domestic guinea pig , degu , thirteen-lined ground squirrel , bald eagle , green monkey

Categories: Vision / eye phene

Mendelian trait/disorder: yes

Disease-related: yes

Key variant known: no

Key variant is published: no

Cross-species summary: Opacity of the lens of the eye.

Inheritance: Genetic and non-genetic forms of cataract exist. Detlefson and Yapp (1920) reported convincing evidence of single-locus autosomal recessive inheritance in US Holsteins, involving 70 offspring from the test mating of a bull and one of his sons to daughters of the bull. Gregory et al. (1943) reported equally convincing data involving what appeared to be the same defect in US Jerseys. In contrast, Ashton et al. (1977) discounted hereditary involvement in "two outbreaks of congenital cataract in [Holstein-Friesian] dairy herds" in the UK.

Breeds: Holstein (black and white) (Cattle) (VBO_0000237), Jersey (Cattle) (VBO_0000250).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).