OMIA:000279-9823 : Diabetes mellitus in Sus scrofa |
In other species: dog , domestic cat , horse , taurine cattle , rabbit , domestic guinea pig , long-tailed chinchilla , koala
Categories: Endocrine / exocrine gland phene (incl mammary gland)
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 125850 (trait) , 125851 (trait) , 125852 (trait) , 125853 (trait) , 176730 (gene) , 222100 (trait) , 222300 (trait) , 520000 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific description: Renner et al. (2013): "generated INS(C94Y) transgenic pigs. ... The stable diabetic phenotype and its rescue by insulin treatment make the INS(C94Y) transgenic pig an attractive model for insulin supplementation and islet transplantation trials, and for studying developmental consequences of maternal diabetes mellitus." Genetically-modified organism, GMO
Cho et al. (2018) "have successfully generated insulin-deficient pigs by generating the indels of the porcine INS gene in somatic cells using CRISPR/Cas9 system followed by somatic cell nuclear transfer. ... As expected, INS knockout piglets presented high blood glucose levels and glucose was detected in the urine." Genetically-modified organism, GMO
Peng et al. (2023) "established diabetes-susceptible transgenic pigs [PIGinH11 pigs] and subjected them to high-fat and high-sucrose dietary interventions. ... Compared to wild-type (WT) pigs, PIGinH11 pigs showed similar pathological manifestations to type 2 diabetes patients ... ." Genetically-modified organism, GMO
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| INS | insulin | Sus scrofa | 2 | NC_010444.4 (1498052..1496842) | INS | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000279-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Lutz, T.A. : |
| Mammalian models of diabetes mellitus, with a focus on type 2 diabetes mellitus. Nat Rev Endocrinol 19:350-360, 2023. Pubmed reference: 36941447 . DOI: 10.1038/s41574-023-00818-3. | |
| Peng, H., Zhang, K., Miao, J., Yang, Y., Xu, S., Wu, T., Tao, C., Wang, Y., Yang, S. : | |
| SnRNA-Seq of pancreas revealed the dysfunction of endocrine and exocrine cells in transgenic pigs with prediabetes. Int J Mol Sci 24:, 2023. Pubmed reference: 37175407 . DOI: 10.3390/ijms24097701. | |
| Shashikadze, B., Valla, L., Lombardo, S.D., Prehn, C., Haid, M., Riols, F., Stöckl, J.B., Elkhateib, R., Renner, S., Rathkolb, B., Menche, J., Hrabĕ de Angelis, M., Wolf, E., Kemter, E., Fröhlich, T. : | |
| Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model. Mol Metab 75:101768, 2023. Pubmed reference: 37414142 . DOI: 10.1016/j.molmet.2023.101768. | |
| Yagihashi, S. : | |
| Contribution of animal models to diabetes research: Its history, significance, and translation to humans. J Diabetes Investig :, 2023. Pubmed reference: 37401013 . DOI: 10.1111/jdi.14034. | |
| 2022 | Xu, J., Zhang, K., Qiu, B., Liu, J., Liu, X., Yang, S., Xiao, X. : |
| Decreased hyocholic acid and lysophosphatidylcholine induce elevated blood glucose in a transgenic porcine model of metabolic disease. Metabolites 12:, 2022. Pubmed reference: 36557202 . DOI: 10.3390/metabo12121164. | |
| 2021 | Kemter, E., Citro, A., Wolf-van Buerck, L., Qiu, Y., Böttcher, A., Policardi, M., Pellegrini, S., Valla, L., Alunni-Fabbroni, M., Kobolák, J., Kessler, B., Kurome, M., Zakhartchenko, V., Dinnyes, A., Cyran, C.C., Lickert, H., Piemonti, L., Seissler, J., Wolf, E. : |
| Transgenic pigs expressing near infrared fluorescent protein-A novel tool for noninvasive imaging of islet xenotransplants. Xenotransplantation :e12719, 2021. Pubmed reference: 34935207 . DOI: 10.1111/xen.12719. | |
| Tanihara, F., Hirata, M., Otoi, T. : | |
| Current status of the application of gene editing in pigs. J Reprod Dev 67:177-187, 2021. Pubmed reference: 33840678 . DOI: 10.1262/jrd.2021-025. | |
| Zhang, J., Khazalwa, E.M., Abkallo, H.M., Zhou, Y., Nie, X., Ruan, J., Zhao, C., Wang, J., Xu, J., Li, X., Zhao, S., Zuo, E., Steinaa, L., Xie, S. : | |
| The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research. J Genet Genomics 48:347-360, 2021. Pubmed reference: 34144928 . DOI: 10.1016/j.jgg.2021.03.015. | |
| 2018 | Cho, B., Kim, S.J., Lee, E.J., Ahn, S.M., Lee, J.S., Ji, D.Y., Lee, K., Kang, J.T. : |
| Generation of insulin-deficient piglets by disrupting INS gene using CRISPR/Cas9 system. Transgenic Res 27:289-300, 2018. Pubmed reference: 29691708 . DOI: 10.1007/s11248-018-0074-1. | |
| 2013 | Renner, S., Braun-Reichhart, C., Blutke, A., Herbach, N., Emrich, D., Streckel, E., Wünsch, A., Kessler, B., Kurome, M., Bähr, A., Klymiuk, N., Krebs, S., Puk, O., Nagashima, H., Graw, J., Blum, H., Wanke, R., Wolf, E. : |
| Permanent neonatal diabetes in INS(C94Y) transgenic pigs. Diabetes 62:1505-11, 2013. Pubmed reference: 23274907 . DOI: 10.2337/db12-1065. |
Edit History
- Created by Imke Tammen2 on 25 Jun 2021
- Changed by Imke Tammen2 on 25 Jun 2021
- Changed by Imke Tammen2 on 26 Dec 2021
- Changed by Imke Tammen2 on 15 May 2023
- Changed by Imke Tammen2 on 20 Jul 2023