OMIA 000279-9823 : Diabetes mellitus in Sus scrofa

In other species: dog , domestic cat , horse , cattle , rabbit , golden hamster , domestic guinea pig , long-tailed chinchilla , koala

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 125850 (trait) , 125851 (trait) , 125852 (trait) , 125853 (trait) , 176730 (gene) , 222100 (trait) , 222300 (trait) , 520000 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Genetically-modified organism, GMO

Cho et al. (2018) "have successfully generated insulin-deficient pigs by generating the indels of the porcine INS gene in somatic cells using CRISPR/Cas9 system followed by somatic cell nuclear transfer. ... As expected, INS knockout piglets presented high blood glucose levels and glucose was detected in the urine."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
INS insulin Sus scrofa 2 NC_010444.4 (1498052..1496842) INS Homologene, Ensembl, NCBI gene


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Kemter, E., Citro, A., Wolf-van Buerck, L., Qiu, Y., Böttcher, A., Policardi, M., Pellegrini, S., Valla, L., Alunni-Fabbroni, M., Kobolák, J., Kessler, B., Kurome, M., Zakhartchenko, V., Dinnyes, A., Cyran, C.C., Lickert, H., Piemonti, L., Seissler, J., Wolf, E. :
Transgenic pigs expressing near infrared fluorescent protein-A novel tool for noninvasive imaging of islet xenotransplants. Xenotransplantation :e12719, 2021. Pubmed reference: 34935207. DOI: 10.1111/xen.12719.
Tanihara, F., Hirata, M., Otoi, T. :
Current status of the application of gene editing in pigs. J Reprod Dev 67:177-187, 2021. Pubmed reference: 33840678. DOI: 10.1262/jrd.2021-025.
Zhang, J., Khazalwa, E.M., Abkallo, H.M., Zhou, Y., Nie, X., Ruan, J., Zhao, C., Wang, J., Xu, J., Li, X., Zhao, S., Zuo, E., Steinaa, L., Xie, S. :
The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research. J Genet Genomics 48:347-360, 2021. Pubmed reference: 34144928. DOI: 10.1016/j.jgg.2021.03.015.
2018 Cho, B., Kim, S.J., Lee, E.J., Ahn, S.M., Lee, J.S., Ji, D.Y., Lee, K., Kang, J.T. :
Generation of insulin-deficient piglets by disrupting INS gene using CRISPR/Cas9 system. Transgenic Res 27:289-300, 2018. Pubmed reference: 29691708. DOI: 10.1007/s11248-018-0074-1.

Edit History

  • Created by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 26 Dec 2021