OMIA 000319-9615 : Ears, folded (drop vs prick) in Canis lupus familiaris

In other species: domestic cat

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 113500 , 606835 , 606071 , 156530 , 168400 , 181405 , 184095 , 600175 , 184252

Mendelian trait/disorder: unknown

Considered a defect: no

Species-specific name: Floppy ears versus erect ears; drop ears versus prick ears

Mapping: Jones et al. (2008) conducted an across-breed GWAS on 2,801 dogs from 147 breeds, each genotyped for 674 equally spaced SNPs, plus an additional 862 SNPs located in regions of interest. The results highlighted a region on CFA34, and regions of lower significance on CFA10, 15 and 32.

By conducting a mammoth GWAS on "915 dogs representing 80 American Kennel Club (AKC) recognized breeds as well as 83 wild canids that included wolves, jackals, and coyotes and 10 Egyptian shelter dogs", each genotyped with the Affymetrix v2 Canine SNP chip (yielding 60,968 informative SNPs for analysis, based on a novel screening algorithm, MAGIC), Boyco et al. (2010) "found a single region on CFA10 that is likely responsible for the difference in ear type [floppy versus erect]".

By conducting an equally mammoth proof-of-principle GWAS on "12 breeds with pricked ears and 15 breeds with dropped ears", with each dog being genotyped with Illumina CanineHD array (yielding 157,393 SNPs for analysis) developed for this study, Vaysse et al. (2011) confirmed the results of Boyco et al. (2011) by highlighting a region between 10.27 and 11.79Mb on chromosome CFA10.

Molecular basis: Chew et al. (2019): "A new possible functional variant in MSRB3 is identified in this study (g. 8038433del>ins). At this locus, the Dingo has a 5-base insertion variant (g. 8038433del>insTTTAT). All Kelpies have a 10 bp insertion at the same locus (g. 8038433del>insTTTATTTTAT)."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
MSRB3 methionine sulfoxide reductase B3 Canis lupus familiaris 10 NC_006592.3 (7892745..8040196) MSRB3 Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 Chew, T., Willet, C.E., Haase, B., Wade, C.M. :
Genomic Characterization of External Morphology Traits in Kelpies Does Not Support Common Ancestry with the Australian Dingo. Genes (Basel) 10:, 2019. Pubmed reference: 31058880. DOI: 10.3390/genes10050337.
2015 Webster, M.T., Kamgari, N., Perloski, M., Hoeppner, M.P., Axelsson, E., Hedhammar, Å., Pielberg, G., Lindblad-Toh, K. :
Linked genetic variants on chromosome 10 control ear morphology and body mass among dog breeds. BMC Genomics 16:474, 2015. Pubmed reference: 26100605. DOI: 10.1186/s12864-015-1702-2.
2011 Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Rosengren Pielberg, G., Sigurdsson, S., Fall, T., Seppälä, E.H., Hansen, M.S., Lawley, C.T., Karlsson, E.K. :
Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping. PLoS Genet 7:e1002316, 2011. Pubmed reference: 22022279. DOI: 10.1371/journal.pgen.1002316.
2010 Boyko, A.R., Quignon, P., Li, L., Schoenebeck, J.J., Degenhardt, J.D., Lohmueller, K.E., Zhao, K., Brisbin, A., Parker, H.G., vonHoldt, B.M., Cargill, M., Auton, A., Reynolds, A., Elkahloun, A.G., Castelhano, M., Mosher, D.S., Sutter, N.B., Johnson, G.S., Novembre, J., Hubisz, M.J., Siepel, A., Wayne, R.K., Bustamante, C.D., Ostrander, E.A. :
A simple genetic architecture underlies morphological variation in dogs. PLoS Biol 8:e1000451, 2010. Pubmed reference: 20711490. DOI: 10.1371/journal.pbio.1000451.
2008 Jones, P., Chase, K., Martin, A., Davern, P., Ostrander, EA., Lark, KG. :
Single-nucleotide-polymorphism-based association mapping of dog stereotypes. Genetics 179:1033-44, 2008. Pubmed reference: 18505865. DOI: 10.1534/genetics.108.087866.

Edit History


  • Created by Frank Nicholas on 21 May 2013
  • Changed by Frank Nicholas on 21 May 2013
  • Changed by Frank Nicholas on 22 May 2013
  • Changed by Frank Nicholas on 03 Jun 2019