OMIA:000319-9615 : Ears, folded (drop vs prick) in Canis lupus familiaris
In other species: domestic cat , pig , sheep
Categories: Hearing / vestibular / ear phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 113500 (trait) , 606835 (trait) , 606071 (trait) , 156530 (trait) , 168400 (trait) , 181405 (trait) , 184095 (trait) , 600175 (trait) , 184252 (trait) , 605427 (gene) , 613719 (gene) , 613718 (trait) , 617383 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: no
Species-specific name: Floppy ears versus erect ears; drop ears versus prick ears
Mapping: Jones et al. (2008) conducted an across-breed GWAS on 2,801 dogs from 147 breeds, each genotyped for 674 equally spaced SNPs, plus an additional 862 SNPs located in regions of interest. The results highlighted a region on CFA34, and regions of lower significance on CFA10, 15 and 32.
By conducting a mammoth GWAS on "915 dogs representing 80 American Kennel Club (AKC) recognized breeds as well as 83 wild canids that included wolves, jackals, and coyotes and 10 Egyptian shelter dogs", each genotyped with the Affymetrix v2 Canine SNP chip (yielding 60,968 informative SNPs for analysis, based on a novel screening algorithm, MAGIC), Boyco et al. (2010) "found a single region on CFA10 that is likely responsible for the difference in ear type [floppy versus erect]".
By conducting an equally mammoth proof-of-principle GWAS on "12 breeds with pricked ears and 15 breeds with dropped ears", with each dog being genotyped with Illumina CanineHD array (yielding 157,393 SNPs for analysis) developed for this study, Vaysse et al. (2011) confirmed the results of Boyco et al. (2011) by highlighting a region between 10.27 and 11.79Mb on chromosome CFA10.
Molecular basis: Chew et al. (2019): "A new possible functional variant in MSRB3 is identified in this study (g. 8038433del>ins). At this locus, the Dingo has a 5-base insertion variant (g. 8038433del>insTTTAT). All Kelpies have a 10 bp insertion at the same locus (g. 8038433del>insTTTATTTTAT)."
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|MSRB3||methionine sulfoxide reductase B3||Canis lupus familiaris||10||NC_051814.1 (7971606..8151219)||MSRB3||Homologene, Ensembl , NCBI gene|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2019||Chew, T., Willet, C.E., Haase, B., Wade, C.M. :|
|Genomic characterization of external morphology traits in kelpies does not support common ancestry with the Australian dingo. Genes (Basel) 10:337, 2019. Pubmed reference: 31058880 . DOI: 10.3390/genes10050337.|
|Dreger, D.L., Hooser, B.N., Hughes, A.M., Ganesan, B., Donner, J., Anderson, H., Holtvoigt, L., Ekenstedt, K.J. :|
|True Colors: Commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential. PLoS One 14:e0223995, 2019. Pubmed reference: 31658272 . DOI: 10.1371/journal.pone.0223995.|
|2015||Webster, M.T., Kamgari, N., Perloski, M., Hoeppner, M.P., Axelsson, E., Hedhammar, Å., Pielberg, G., Lindblad-Toh, K. :|
|Linked genetic variants on chromosome 10 control ear morphology and body mass among dog breeds. BMC Genomics 16:474, 2015. Pubmed reference: 26100605 . DOI: 10.1186/s12864-015-1702-2.|
|2011||Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Rosengren Pielberg, G., Sigurdsson, S., Fall, T., Seppälä, E.H., Hansen, M.S., Lawley, C.T., Karlsson, E.K. :|
|Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping. PLoS Genet 7:e1002316, 2011. Pubmed reference: 22022279 . DOI: 10.1371/journal.pgen.1002316.|
|2010||Boyko, A.R., Quignon, P., Li, L., Schoenebeck, J.J., Degenhardt, J.D., Lohmueller, K.E., Zhao, K., Brisbin, A., Parker, H.G., vonHoldt, B.M., Cargill, M., Auton, A., Reynolds, A., Elkahloun, A.G., Castelhano, M., Mosher, D.S., Sutter, N.B., Johnson, G.S., Novembre, J., Hubisz, M.J., Siepel, A., Wayne, R.K., Bustamante, C.D., Ostrander, E.A. :|
|A simple genetic architecture underlies morphological variation in dogs. PLoS Biol 8:e1000451, 2010. Pubmed reference: 20711490 . DOI: 10.1371/journal.pbio.1000451.|
|2008||Jones, P., Chase, K., Martin, A., Davern, P., Ostrander, EA., Lark, KG. :|
|Single-nucleotide-polymorphism-based association mapping of dog stereotypes. Genetics 179:1033-44, 2008. Pubmed reference: 18505865 . DOI: 10.1534/genetics.108.087866.|
- Created by Frank Nicholas on 21 May 2013
- Changed by Frank Nicholas on 21 May 2013
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- Changed by Frank Nicholas on 03 Jun 2019
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- Changed by Imke Tammen2 on 28 Aug 2021