OMIA 000344-10036 : Epilepsy in Mesocricetus auratus |
In other species:
cattle
,
chicken
,
dog
,
rabbit
,
domestic cat
,
Mongolian gerbil
,
horse
,
white-tufted-ear marmoset
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers):
104130 (trait)
,
117100 (trait)
,
121200 (trait)
,
121201 (trait)
,
125370 (trait)
,
132090 (trait)
,
132100 (trait)
,
132300 (trait)
,
159600 (trait)
,
182610 (trait)
,
203600 (trait)
,
208700 (trait)
,
220300 (trait)
,
226750 (trait)
,
226800 (trait)
,
226810 (trait)
,
226850 (trait)
,
254770 (trait)
,
254780 (trait)
,
254800 (trait)
,
266270 (trait)
,
267740 (trait)
,
270805 (trait)
,
301900 (trait)
,
310370 (trait)
,
545000 (trait)
,
600131 (trait)
,
600143 (trait)
,
600512 (trait)
,
600513 (trait)
,
600669 (trait)
,
601068 (trait)
,
245570 (trait)
Mendelian trait/disorder:
no
Mode of inheritance:
Multifactorial
Considered a defect:
yes
Key variant known:
no
History:
As summarised by Muñoz et al. (2017): "The hamster has been previously described as a paroxysmal dystonia model, but our strain is currently recognized as a model of audiogenic seizures (AGS). The original first epileptic hamster appeared spontaneously at the University of Valladolid, where it was known as the GPG:Vall line, and was transferred to the University of Salamanca where a new strain was developed, named GASH:Sal."
Markers:
Díaz-Casado et al. (2020) "performed whole exome sequencing (WES) in GASH/Sal animals and their corresponding controls to identify and characterize the mutational landscape of the GASH/Sal strain . . . [from which] 3 high-impact and 15 moderate-impact variants were identified", thereby providing strong evidence of the mutifactorial nature of this disorder.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 | Fuerte-Hortigón, A., Gonçalves, J., Zeballos, L., Masa, R., Gómez-Nieto, R., López, D.E. : | |
Distribution of the Cannabinoid Receptor Type 1 in the Brain of the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal. Front Behav Neurosci 15:613798, 2021. Pubmed reference: 33841106. DOI: 10.3389/fnbeh.2021.613798. | ||
2020 | Díaz-Casado, E., Gómez-Nieto, R., de Pereda, J.M., Muñoz, L.J., Jara-Acevedo, M., López, D.E. : | |
Analysis of gene variants in the GASH/Sal model of epilepsy. PLoS One 15:e0229953, 2020. Pubmed reference: 32168507. DOI: 10.1371/journal.pone.0229953. | ||
Díaz-Rodríguez, S.M., López-López, D., Herrero-Turrión, M.J., Gómez-Nieto, R., Canal-Alonso, A., Lopéz, D.E. : | ||
Inferior Colliculus Transcriptome After Status Epilepticus in the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal. Front Neurosci 14:508, 2020. Pubmed reference: 32528245. DOI: 10.3389/fnins.2020.00508. | ||
Sánchez-Benito, D., Hyppolito, M.A., Alvarez-Morujo, A.J., López, D.E., Gómez-Nieto, R. : | ||
Morphological and molecular correlates of altered hearing sensitivity in the genetically audiogenic seizure-prone hamster GASH/Sal. Hear Res 392:107973, 2020. Pubmed reference: 32402894. DOI: 10.1016/j.heares.2020.107973. | ||
2017 | Barrera-Bailón, B., Oliveira, J.A.C., López, D.E., Muñoz, L.J., Garcia-Cairasco, N., Sancho, C. : | |
Pharmacological and neuroethological study of the acute and chronic effects of lamotrigine in the genetic audiogenic seizure hamster (GASH:Sal). Epilepsy Behav 71:207-217, 2017. Pubmed reference: 26876275. DOI: 10.1016/j.yebeh.2015.11.005. | ||
López-López, D., Gómez-Nieto, R., Herrero-Turrión, M.J., García-Cairasco, N., Sánchez-Benito, D., Ludeña, M.D., López, D.E. : | ||
Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in two strains of rodents susceptible to audiogenic seizures. Epilepsy Behav 71:226-237, 2017. Pubmed reference: 26775236. DOI: 10.1016/j.yebeh.2015.12.020. | ||
Muñoz, L.J., Carballosa-Gautam, M.M., Yanowsky, K., García-Atarés, N., López, D.E. : | ||
The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal. Epilepsy Behav 71:181-192, 2017. Pubmed reference: 27072920. DOI: 10.1016/j.yebeh.2016.03.002. | ||
Prieto-Martín, A.I., Aroca-Aguilar, J.D., Sánchez-Sánchez, F., Muñoz, L.J., López, D.E., Escribano, J., de Cabo, C. : | ||
Molecular and neurochemical substrates of the audiogenic seizure strains: The GASH:Sal model. Epilepsy Behav 71:218-225, 2017. Pubmed reference: 26071997. DOI: 10.1016/j.yebeh.2015.05.025. | ||
Sánchez-Benito, D., Gómez-Nieto, R., Hernández-Noriega, S., Murashima, A.A.B., de Oliveira, J.A.C., Garcia-Cairasco, N., López, D.E., Hyppolito, M.A. : | ||
Morphofunctional alterations in the olivocochlear efferent system of the genetic audiogenic seizure-prone hamster GASH:Sal. Epilepsy Behav 71:193-206, 2017. Pubmed reference: 27492627. DOI: 10.1016/j.yebeh.2016.05.040. | ||
2013 | Barrera-Bailón, B., Oliveira, J.A., López, D.E., Muñoz, L.J., Garcia-Cairasco, N., Sancho, C. : | |
Pharmacological and neuroethological studies of three antiepileptic drugs in the Genetic Audiogenic Seizure Hamster (GASH:Sal). Epilepsy Behav 28:413-25, 2013. Pubmed reference: 23872084. DOI: 10.1016/j.yebeh.2013.05.028. | ||
Carballosa-Gonzalez, M.M., Muñoz, L.J., López-Alburquerque, T., Pardal-Fernández, J.M., Nava, E., de Cabo, C., Sancho, C., López, D.E. : | ||
EEG characterization of audiogenic seizures in the hamster strain GASH:Sal. Epilepsy Res 106:318-25, 2013. Pubmed reference: 23916142. DOI: 10.1016/j.eplepsyres.2013.07.001. | ||
2012 | Prieto-Martín, A.I., Llorens, S., Pardal-Fernández, J.M., Muñoz, L.J., López, D.E., Escribano, J., Nava, E., de Cabo, C. : | |
Opposite caudal versus rostral brain nitric oxide synthase response to generalized seizures in a novel rodent model of reflex epilepsy. Life Sci 90:531-7, 2012. Pubmed reference: 22326500. DOI: 10.1016/j.lfs.2012.01.010. | ||
2008 | Fuentes-Santamaría, V., Alvarado, J.C., Herranz, A.S., García-Atarés, N., López, D.E. : | |
Decreased levels of GABA in the inferior colliculus of the epilepsy-prone hamster (GPG/Vall). Epilepsy Res 79:224-7, 2008. Pubmed reference: 18372163. DOI: 10.1016/j.eplepsyres.2008.02.003. | ||
2007 | Fuentes-Santamaría, V., Alvarado, J.C., Herranz, A.S., García-Atarés, N., López, D.E. : | |
Morphologic and neurochemical alterations in the superior colliculus of the genetically epilepsy-prone hamster (GPG/Vall). Epilepsy Res 75:206-19, 2007. Pubmed reference: 17628427. DOI: 10.1016/j.eplepsyres.2007.06.005. | ||
2005 | Fuentes-Santamaría, V., Cantos, R., Alvarado, J.C., García-Atarés, N., López, D.E. : | |
Morphologic and neurochemical abnormalities in the auditory brainstem of the genetically epilepsy-prone hamster (GPG/Vall). Epilepsia 46:1027-45, 2005. Pubmed reference: 16026555. DOI: 10.1111/j.1528-1167.2005.68104.x. |
Edit History
- Created by Frank Nicholas on 31 Oct 2016
- Changed by Frank Nicholas on 15 Mar 2020