OMIA:000374-8932 : Feather colour, extended black in Columba livia
In other species: chicken , red-footed booby , black swan , Coscoroba swan , Bananaquit , helmeted guineafowl , gyrfalcon , Lesser snow goose , Arctic skua , Chestnut-bellied monarch , brown booby , zebra finch , ruff , Eleonora's falcon , pomarine skua , king penguin , Mallard
Categories: Pigmentation phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 266300 (trait) , 155555 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: yes
Markers: Ran et al. (2016) reported "three single nucleotide polymorphisms (SNPs) [in MC1R] were detected, including G199A, G225A, and A466G, which subsequently determined four haplotypes (H1-H4). Among them, H1 is the predominant haplotype. Association analysis revealed that H1 and H3 were significantly associated with the black plumage trait (P < 0.05), while the H4 was significantly associated with gray plumage trait (P < 0.05). Furthermore, only diplotype H1H1 was significantly associated with black and gray traits of pigeons." None of these associations appears to be sufficient to justify concluding that any of these polymorphisms is a likely causal variant.
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2016||Ran, J.S., You, X.Y., Jin, J., Zhou, Y.G., Wang, Y., Lan, D., Ren, P., Liu, Y.P. :|
|The Relationship between <i>MC1R</i> Mutation and Plumage Color Variation in Pigeons. Biomed Res Int 2016:3059756, 2016. Pubmed reference: 27957493 . DOI: 10.1155/2016/3059756.|
|2013||Derelle, R., Kondrashov, F.A., Arkhipov, V.Y., Corbel, H., Frantz, A., Gasparini, J., Jacquin, L., Jacob, G., Thibault, S., Baudry, E. :|
|Color differences among feral pigeons (Columba livia) are not attributable to sequence variation in the coding region of the melanocortin-1 receptor gene (MC1R). BMC Res Notes 6:310, 2013. Pubmed reference: 23915680 . DOI: 10.1186/1756-0500-6-310.|
|Guernsey, M.W., Ritscher, L., Miller, M.A., Smith, D.A., Schöneberg, T., Shapiro, M.D. :|
|A Val85Met mutation in melanocortin-1 receptor is associated with reductions in eumelanic pigmentation and cell surface expression in domestic rock pigeons (Columba livia). PLoS One 8:e74475, 2013. Pubmed reference: 23977400 . DOI: 10.1371/journal.pone.0074475.|
- Changed by Frank Nicholas on 02 Apr 2020
- Created by Frank Nicholas on 02 Apr 2020