OMIA:000393-9823 : Tetragametic chimerism (including Freemartin) in Sus scrofa |
In other species: taurine cattle , deer , sheep , bighorn sheep , water buffalo , dog , horse
Categories: Reproductive system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: Tetragametic chimerism is a rare, sex chromosome disorder of sex development characterized by the two different haploid sets of maternal and paternal chromosomes and variable phenotype - from normal male or female genitalia, to different degrees of ambiguous genitalia, and often infertility. Also, in the cases of monochorionic dizygotic twins, it can be confined to blood of both twins. [ Orphanet : 199310 ] Freemartin or free-martin is an infertile female animal which is the twin of a male animal whose anti-Müllerian hormones affected its development in utero. Genetically the animals are chimeric (microchimerism, XX/XY leukocyte chimerism) - some stem cells from the male twin are received during in utero development via vascular connections between placentas. The condition is mostly reported in ruminants due to their multicotyledonary placenta type. Phene was renamed to 'Tetragametic chimerism' [16/11/2022]
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:000393-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 1988 | Romagnano, A., Tiemann, M., Niar, A., Helie, O., King, W.A. : |
| [Freemartinism in domestic animals] Medicin veterinaire du Quebec 18:79-84, 1988. | |
| 1987 | Syed, M., Nes, N., Ronningen, K. : |
| The significance of chromosome studies in animal breeding in Norway Journal of Animal Breeding and Genetics 104:113-120, 1987. | |
| 1982 | Ollivier, L., Sellier, P. : |
| Pig genetics: a review Annales de Genetique et de Selection Animale 14:481-544, 1982. | |
| 1968 | Bruere, A.N., Fielden, E.D., Hutchings, H. : |
| XX/XY mosaicism in lymphocyte cultures from a pig with freemartin characteristics New Zealand Veterinary Journal 16:31-38, 1968. Pubmed reference: 5241942 . DOI: 10.1080/00480169.1968.33743. | |
| 1965 | Bertrand, M. : |
| [Freemartinism] Revue de Medecine Veterinaire 116:575-596, 1965. |
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- Created by Frank Nicholas on 06 Sep 2005