OMIA 000393-9913 : Freemartin in Bos taurus

In other species: dog , pig , deer , sheep , bighorn sheep , water buffalo

Mendelian trait/disorder: unknown

Considered a defect: yes


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2003 Meinecke, B., Kuiper, H., Drogemuller, C., Leeb, T., Meinecke-Tillmann, S. :
A mola hydatidosa coexistent with a foetus in a bovine freemartin pregnancy Placenta 24:107-12, 2003. Pubmed reference: 12495666.
1999 Cavalieri, J., Farin, P.W. :
Birth of a Holstein freemartin calf co-twinned to a schistosomus reflexus fetus Theriogenology 52:815-826, 1999. Pubmed reference: 10735122.
Ennis, S., Vaughan, L., Gallagher, T.F. :
The diagnosis of freemartinism in cattle using sex-specific DNA sequences Research in Veterinary Science 67:111-112, 1999. Pubmed reference: 10425251. DOI: 10.1053/rvsc.1998.0286.
Kannan, T.P., Thangaraju, P., Asokan, S.A. :
Karyological study of a Holstein Friesian crossbred freemartin Indian Veterinary Journal 76:450-451, 1999.
Nouri, M., Kohli, R.N. :
Induction of lactation in two freemartin heifers Indian Journal of Animal Sciences 69:413-414, 1999.
1997 Jankowski, R.A., Ildstad, S.T. :
Chimerism and tolerance - from freemartin cattle to neonatal mice to humans Human Immunology 52:155-161, 1997. Pubmed reference: 9077564. DOI: 10.1016/S0198-8859(96)00290-X.
Mommens, G., Vanzeveren, A., Peelman, L. :
Detection of freemartins by a Y chromosome specific DNA sequence [Dutch] Vlaams Diergeneeskundig Tijdschrift 66:88-92, 1997.
Satoh, S., Hirata, T.I., Miyake, Y.I., Kaneda, Y. :
The possibility of early estimation for fertility in bovine heterosexual twin females Journal of Veterinary Medical Science 59:221-222, 1997. Pubmed reference: 9101484.
1995 Fujishiro, A., Kawakura, K., Miyake, Y.I., Kaneda, Y. :
A fast, convenient diagnosis of the bovine freemartin syndrome using polymerase chain reaction Theriogenology 43:883-891, 1995.
Justi, A., Hecht, W., Herzog, A., Speck, J. :
Comparison of different methods for the diagnosis of freemartins - polymerase chain reaction, blood group serology and karyotyping [German] Deutsche Tierarztliche Wochenschrift 102:471-474, 1995. Pubmed reference: 8591746.
Kadokawa, H., Minezawa, M., Yamamoto, Y., Takahashi, M., Shimada, K., Takahashi, H., Kariya, T. :
Freemartinism among singleton bovine females born from multiple embryo transfer Theriogenology 44:295-306, 1995.
1994 Edwards, J.F., Gallagher, D.S., Prakash, B. :
Urethral Atresia with Uroperitoneum in a Newborn Bovine Freemartin Veterinary Pathology 31:117-119, 1994. Pubmed reference: 8140717.
Khan, M.Z., Foley, G.L. :
Retrospective Studies on the Measurements, Karyotyping and Pathology of Reproductive Organs of Bovine Freemartins Journal of Comparative Pathology 110:25-36, 1994. Pubmed reference: 8040370.
1993 Olsaker, I., Jorgensen, C.B., Hellemann, A.L., Thomsen, P.D., Lie, O. :
A Fast and Highly Sensitive Method for Detecting Freemartinism in Bovine Twins Using Immunomagnetic Beads and Y-Specific PCR Primers Animal Genetics 24:311-313, 1993. Pubmed reference: 8239077.
Vanhaeringen, H., Hradil, R. :
Twins in Cattle - A Freemartin or Not - An Update Tijdschrift Voor Diergeneeskunde 118:648-649, 1993. Pubmed reference: 8236226.
1992 Buoen, L.C., Zhang, T.Q., Weber, A.F., Anderson, M.R., Ruth, G.R. :
The Requirement of Fibroblasts to Confirm the Identity of Cytogenetic Centric Fusion (CF) Carriers in Same-Sex Twin Cattle Journal of Veterinary Diagnostic Investigation 4:212-214, 1992. Pubmed reference: 1616994.
Fernandezgarcia, J.L., Martineztrancon, M., Rabasco, A., Padilla, J.A. :
A Case of 1/29 Robertsonian Translocation in Both Cellular Lines of a Freemartin Heifer Journal of Heredity 83:393-395, 1992.
Grobet, L., Charlier, C., Schwers, A., Hanset, R. :
Detection of Freemartinism by Means of DNA Finger Prints and of a Bovine Y-Specific Probe [French] Annales de Medecine Veterinaire 136:41-50, 1992.
Plante, Y., Schmutz, S.M., Lang, K.D.M., Moker, J.S. :
Detection of Leucochimaerism in Bovine Twins by DNA Fingerprinting Animal Genetics 23:295-302, 1992. Pubmed reference: 1503268.
Schellander, K., Peli, J., Taha, T.A., Kopp, E., Mayr, B. :
Diagnosis of Bovine Freemartinism by the Polymerase Chain Reaction Method Animal Genetics 23:549-551, 1992. Pubmed reference: 1362861.
Separovic, E.R., Soldatovic, B., Veselinovic, S., Medic, D., Andjelkovic, M. :
Structural Changes on Chromosomes of Heterosexual Cattle Twins Acta Veterinaria - Beograd 42:15-19, 1992.
1991 Grobet, L., Charlier, C., Hanset, R. :
DNA Fingerprints and Leucochimerism in Bovine Dizygotic Twins Annales de Medecine Veterinaire 135:353-360, 1991.
1990 Dominguez, M.M., Liptrap, R.M., Croy, B.A., Basrur, P.K. :
Hormonal Correlates of Ovarian Alterations in Bovine Freemartin Fetuses Animal Reproduction Science 22:181-201, 1990.
1989 Murakami, R.K., Miyake, Y.I., Kaneda, Y. :
Cases of XY Female, Single-Birth Freemartin and Trisomy (61, XX, +20) Observed in Cytogenetical Studies on 18 Sterile Heifers Japanese Journal of Veterinary Science 51:941-945, 1989. Pubmed reference: 2607745.
1988 Desai, D.S., Krishnaswamy, A., Narayana, K., Nagaraja, C.S., Degde, B.P. :
Cytogenetic studies on heterosexual twins in cattle Indian Journal of Dairy Science 41:21-23, 1988.
Romagnano, A., Tiemann, M., Niar, A., Helie, O., King, W.A. :
[Freemartinism in domestic animals] Medicin veterinaire du Quebec 18:79-84, 1988.
1987 Syed, M., Nes, N., Ronningen, K. :
The significance of chromosome studies in animal breeding in Norway Journal of Animal Breeding and Genetics 104:113-120, 1987.
1986 Rajcan-Separovic, E., Soldatovic, B., Ninkov, D., Zimonjic, D. :
[Cytogenetic and anatomical examination of freemartin heifers] Veterinarski Glasnik 40:447-452, 1986.
1981 Dunn, H.O., Johnson, R.H., Quaas, R.L. :
Sample size for detection of Y-chromosomes in lymphocytes of possible freemartins Cornell Veterinarian 71:297-304, 1981. Pubmed reference: 7196308.
1979 Dunn, H.O., McEntee, K., Hall, C.E., Johnson, R.H.Jr., Stone, W.H. :
Cytogenetic and reproductive studies of bulls born co-twin with freemartins Journal of Reproduction and Fertility 57:21-30, 1979. Pubmed reference: 574547.
1978 Kastli, F., Hall, J.G. :
Cattle twins and freemartin diagnosis Veterinary Record 102:80-83, 1978. Pubmed reference: 636235.
1977 Dain, A.R., Bridge, P.S. :
A freemartin calf with XX/XXY mosaicism Annales de Genetique et de Selection Animale 9:533 only, 1977.
Eldridge, F.E., Blazak, W.F. :
Chromosomal analysis of fertile female heterosexual twins in cattle Journal of Dairy Science 60:458-463, 1977. Pubmed reference: 845292. DOI: 10.3168/jds.S0022-0302(77)83888-5.
1974 Marcum, J.B. :
The freemartin syndrome Animal Breeding Abstracts 42:227-242, 1974.
1969 Short, R.V., Smith, J., Mann, T., Evans, E.R., Hallett, J., Fryer, A., Hamerton, J.L. :
Cytogenetic and endocrine studies of a freemartin heifer and its bull co-twin Cytogenetics 8:369-388, 1969. Pubmed reference: 5823570.
1965 Bertrand, M. :
[Freemartinism] Revue de Medecine Veterinaire 116:575-596, 1965.
Jainudeen, M.R., Hafez, E.S.E. :
Attempts to induce bovine freemartinism experimentally Journal of Reproduction and Fertility 10:281-283, 1965. Pubmed reference: 5891100.
Makino, S., Muramoto, J., Ishikawa, T. :
Notes on XX/XY mosaicism in cells of various tissues of heterosexual twins of cattle Proceedings of the Japan Academy 41:414-418, 1965.
1964 Committee for the Control of Sterility, Ghent Vete, School. Report. :
[Committee for the Control of Sterility, Ghent Veterinary School. Report for the year 1963] Vlaams Diergeneeskundig Tijdschrift 33:62-70, 1964.
Rajakoski, E., Hafez, E.S.E. :
Cytological differentiation of fetal bovine gonads Cytogenetics 3:193-200, 1964.
1963 Bouquet, Y., Willems, A.E.R. :
[Some aspects and results of research into blood groups of cattle twins] Annales de Medecine Veterinaire 107:552-580, 1963.
Rajakoski, E., Hafez, E.S.E. :
Derivatives of cortical cords in adult freemartin gonads of bovine quintuplets Anatomical Record 147:457-497, 1963. Pubmed reference: 14101909.
Rajakoski, E., Hafez, E.S.E. :
Gradient transformation of freemartin gonads in Bos taurus Proceedings of the Fifteenth International Congress on Zoology, Washington 2:228 only, 1963.
1962 Gasparski, J. :
[Investigations on cattle twins. Attempts to determine the blood types of cattle twins on the basis of the blood types of their progeny] Roczniki Nauk Rolniczych. Seria B : Zootechniczna 79:167-173, 1962.
Ohno, S., Trujillo, J.M., Stenius, C., Christian, L.C., Teplitz, R.L. :
Possible germ cell chimeras among newborn dizygotic twin calves (Bos taurus) Cytogenetics 1:258-265, 1962. Pubmed reference: 13939685.
1959 Rasmusen, B.A. :
Blood groups, disputed parentage, twins and freemartins in cattle Illinois Veterinarian 2:31-34, 1959.

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  • Created by Frank Nicholas on 06 Sep 2005