OMIA:000393-9940 : Tetragametic chimerism (including Freemartin) in Ovis aries (sheep) |
In other species: dog , horse , pig , red deer , taurine cattle , bighorn sheep , water buffalo
Categories: Reproductive system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: This is a type of sex chromosome difference of sexual development (DSD). Tetragametic chimerism is a rare, sex chromosome difference of sex development characterized by the two different haploid sets of maternal and paternal chromosomes and variable phenotype - from normal male or female genitalia, to different degrees of ambiguous genitalia, and often infertility. Also, in the cases of monochorionic dizygotic twins, it can be confined to blood of both twins. [updated from Orphanet : 199310 ] Freemartin or free-martin is an infertile female animal which is the twin of a male animal whose anti-Müllerian hormones affected its development in utero. Genetically the animals are chimeric (microchimerism, XX/XY leukocyte chimerism) - some stem cells from the male twin are received during in utero development via vascular connections between placentas. The condition is mostly reported in ruminants due to their multicotyledonary placenta type. Phene was renamed to 'Tetragametic chimerism' [16/11/2022]
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:000393-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 1998 | Szatkowska, I., Udala, J., Baranowski, P., Katkiewicz, M., Stepien, J. : |
| Two cases of freemartinism in sheep Acta Veterinaria Brno 67:189 ff., 1998. | |
| 1997 | Lafi, S.Q., Aldarraji, A.M., Hailat, N.Q., Fathalla, M.A. : |
| Ovine freemartinism Indian Veterinary Journal 74:339-340, 1997. | |
| 1996 | Szatkowska, I., Switonski, M. : |
| Evidence on hereditary occurrence of placental anastomoses in heterosexual twins in sheep Hereditas 124:107-110, 1996. Pubmed reference: 8782431. | |
| 1990 | Cribiu, E.P., Durand, V., Chaffaux, S. : |
| Frequency of the freemartinism in Booroola-Merino-Darles. Recueil de Medecine Veterinaire 166:919-922, 1990. | |
| 1989 | Spedding, R.N., Dobson, H. : |
| Diagnosis of freemartinism in sheep Veterinary Record 124:18-19, 1989. Pubmed reference: 2916299. | |
| 1988 | Romagnano, A., Tiemann, M., Niar, A., Helie, O., King, W.A. : |
| [Freemartinism in domestic animals] Medicin veterinaire du Quebec 18:79-84, 1988. | |
| 1987 | Chaffaux, S., Matejka, M., Cribiu, E.P., Crespeau, F., Eychenne, F., Ricordeau, G. : |
| [Cytogenetic, anatomical and histological study of two freemartin Romanov ewes] Recueil de Medecine Veterinaire 163:15-21, 1987. | |
| Matejka, M., Cribiu, E.P., Ricordeau, G., Chaffaux, S. : | |
| [Frequency of freemartinism in Romanov ewes] Recueil de Medecine Veterinaire 163:635-638, 1987. | |
| 1971 | Dain, A : |
| The incidence of freemartinism in sheep Journal of Reproduction and Fertility 24:91-97, 1971. Pubmed reference: 5099639. | |
| 1965 | Bertrand, M. : |
| [Freemartinism] Revue de Medecine Veterinaire 116:575-596, 1965. | |
| Gerneke, W.H. : | |
| Chromosomal evidence of the freemartin condition in sheep - Ovis aries Journal of the South African Veterinary Medical Association 36:99-104, 1965. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005