In other species: dog , domestic cat , goat

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 240200 (trait) , 240300 (trait)

Mendelian trait/disorder: unknown

Disease-related: yes

Cross-species summary: Hypoadrenocorticism, or Addison’s disease, results from insufficient secretion of steroid hormones (glucocorticoids and mineralocorticoids) from the adrenal glands. In primary hypoadrenocorticism the disease is due to changes to the adrenal cortex, while secondary hypoadrenocorticism refers to deficiency of ACTH, produced in the pituitary gland. The disease can be further classified as typical (glucocorticoid and mineralocorticoid deficiency) with typical electrolyte changes or atypical (only glucocorticoid deficiency with no typical electrolyte changes). The atypical cases often progress to become typical.