OMIA 000519-9615 : Hypoadrenocorticism in Canis lupus familiaris

In other species: domestic cat , horse , goat

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 240200 , 240300

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Addison's disease


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2018 Lathan, P., Thompson, A.L. :
Management of hypoadrenocorticism (Addison's disease) in dogs. Vet Med (Auckl) 9:1-10, 2018. Pubmed reference: 30050862. DOI: 10.2147/VMRR.S125617.
2017 Wakayama, J.A., Furrow, E., Merkel, L.K., Armstrong, P.J. :
A retrospective study of dogs with atypical hypoadrenocorticism: a diagnostic cut-off or continuum? J Small Anim Pract :, 2017. Pubmed reference: 28247992. DOI: 10.1111/jsap.12649.
2016 Gold, A.J., Langlois, D.K., Refsal, K.R. :
Evaluation of Basal Serum or Plasma Cortisol Concentrations for the Diagnosis of Hypoadrenocorticism in Dogs. J Vet Intern Med :, 2016. Pubmed reference: 27714859. DOI: 10.1111/jvim.14589.
2015 Hanson, J.M., Tengvall, K., Bonnett, B.N., Hedhammar, Å. :
Naturally Occurring Adrenocortical Insufficiency--An Epidemiological Study Based on a Swedish-Insured Dog Population of 525,028 Dogs. J Vet Intern Med 30:76-84, 2015. Pubmed reference: 26683136. DOI: 10.1111/jvim.13815.
Pedersen, N.C., Brucker, L., Tessier, N.G., Liu, H., Penedo, M.C., Hughes, S., Oberbauer, A., Sacks, B. :
The effect of genetic bottlenecks and inbreeding on the incidence of two major autoimmune diseases in standard poodles, sebaceous adenitis and Addison's disease. Canine Genet Epidemiol 2:14, 2015. Pubmed reference: 26401342. DOI: 10.1186/s40575-015-0026-5.
2014 Boag, A.M., Catchpole, B. :
A review of the genetics of hypoadrenocorticism. Top Companion Anim Med 29:96-101, 2014. Pubmed reference: 25813849. DOI: 10.1053/j.tcam.2015.01.001.
Short, A.D., Catchpole, B., Boag, A.M., Kennedy, L.J., Massey, J., Rothwell, S., Henthorn, P.S., Littman, M.P., Husebye, E., Ollier, B. :
Putative candidate genes for canine hypoadrenocorticism (Addison's disease) in multiple dog breeds. Vet Rec :, 2014. Pubmed reference: 25124887. DOI: 10.1136/vr.102160.
Van Lanen, K., Sande, A. :
Canine hypoadrenocorticism: pathogenesis, diagnosis, and treatment. Top Companion Anim Med 29:88-95, 2014. Pubmed reference: 25813848. DOI: 10.1053/j.tcam.2014.10.001.
2013 Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M. :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021. DOI: 10.2460/javma.242.11.1549.
Massey, J., Boag, A., Short, A.D., Scholey, R.A., Henthorn, P.S., Littman, M.P., Husebye, E., Catchpole, B., Pedersen, N., Mellersh, C.S., Ollier, W.E., Kennedy, L.J. :
MHC class II association study in eight breeds of dog with hypoadrenocorticism. Immunogenetics 65:291-7, 2013. Pubmed reference: 23358933. DOI: 10.1007/s00251-013-0680-2.
Short, A.D., Boag, A., Catchpole, B., Kennedy, L.J., Massey, J., Rothwell, S., Husebye, E., Ollier, B. :
A Candidate Gene Analysis of Canine Hypoadrenocorticism in 3 Dog Breeds. J Hered :, 2013. Pubmed reference: 23997205. DOI: 10.1093/jhered/est051.
2010 Hughes, AM., Jokinen, P., Bannasch, DL., Lohi, H., Oberbauer, AM. :
Association of a dog leukocyte antigen class II haplotype with hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers. Tissue Antigens 75:684-90, 2010. Pubmed reference: 20136772. DOI: 10.1111/j.1399-0039.2010.01440.x.
Klein, SC., Peterson, ME. :
Canine hypoadrenocorticism: part II. Can Vet J 51:179-84, 2010. Pubmed reference: 20436864.
Klein, SC., Peterson, ME. :
Canine hypoadrenocorticism: Part I. Can Vet J 51:63-9, 2010. Pubmed reference: 20357943.
2009 Gow, AG., Gow, DJ., Bell, R., Simpson, JW., Chandler, ML., Evans, H., Berry, JL., Herrtage, ME., Mellanby, RJ. :
Calcium metabolism in eight dogs with hypoadrenocorticism. J Small Anim Pract 50:426-30, 2009. Pubmed reference: 19689671. DOI: 10.1111/j.1748-5827.2009.00757.x.
Hughes, AM., Bannasch, DL., Kellett, K., Oberbauer, AM. :
Examination of candidate genes for hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers. Vet J :, 2009. Pubmed reference: 19931476. DOI: 10.1016/j.tvjl.2009.10.012.
2008 Adamantos, S., Boag, A. :
Total and ionised calcium concentrations in dogs with hypoadrenocorticism. Vet Rec 163:25-6, 2008. Pubmed reference: 18603632.
Lathan, P., Moore, GE., Zambon, S., Scott-Moncrieff, JC. :
Use of a low-dose ACTH stimulation test for diagnosis of hypoadrenocorticism in dogs. J Vet Intern Med 22:1070-3, 2008. Pubmed reference: 18537878. DOI: 10.1111/j.1939-1676.2008.0118.x.
2007 Greco, DS. :
Hypoadrenocorticism in small animals. Clin Tech Small Anim Pract 22:32-5, 2007. Pubmed reference: 17542195. DOI: 10.1053/j.ctsap.2007.02.005.
Hughes, AM., Nelson, RW., Famula, TR., Bannasch, DL. :
Clinical features and heritability of hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers: 25 cases (1994-2006). J Am Vet Med Assoc 231:407-12, 2007. Pubmed reference: 17669043. DOI: 10.2460/javma.231.3.407.
2006 Chase, K., Sargan, D., Miller, K., Ostrander, EA., Lark, KG. :
Understanding the genetics of autoimmune disease: two loci that regulate late onset Addison's disease in Portuguese Water Dogs. Int J Immunogenet 33:179-84, 2006. Pubmed reference: 16712648. DOI: 10.1111/j.1744-313X.2006.00593.x.
Oberbauer, AM., Bell, JS., Belanger, JM., Famula, TR. :
Genetic evaluation of Addison's disease in the Portuguese Water Dog. BMC Vet Res 2:15, 2006. Pubmed reference: 16670022. DOI: 10.1186/1746-6148-2-15.
2005 Jarrett, RH., Norman, EJ., Squires, RA. :
Liquorice and canine Addison's disease. N Z Vet J 53:214, 2005. Pubmed reference: 16012593. DOI: 10.1080/00480169.2005.36508.
Rockwell, J., Monroe, WE., Tromblee, TC. :
Spontaneous hypoadrenocorticism in a dog after a diagnosis of hyperadrenocorticism. J Vet Intern Med 19:299-300, 2005. Pubmed reference: 15822572.
2003 Famula, T.R., Belanger, J.M., Oberbauer, A.M. :
Heritability and complex segregation analysis of hypoadrenocorticism in the standard poodle Journal of Small Animal Practice 44:8-12, 2003. Pubmed reference: 12570345.
2002 Oberbauer, A.M., Benemann, K.S., Belanger, J.M., Wagner, D.R., Ward, J.H., Famula, T.R. :
Inheritance of hypoadrenocorticism in Bearded Collies American Journal of Veterinary Research 63:643-647, 2002. Pubmed reference: 12013462.
2000 Greco, D.S. :
Hypoadrenocorticism in dogs and cats Veterinary Medicine 95:468-+, 2000.
Mansfield, C.S. :
Glucocorticoid deficiency (atypical hypoadrenocorticism) and exocrine pancreatic insufficiency in a German Shepherd Dog Australian Veterinary Practitioner 30:2-5, 2000.
1999 Hoerauf, A., Reusch, C. :
Ultrasonographic evaluation of the adrenal glands in six dogs with hypoadrenocorticism Journal of the American Animal Hospital Association 35:214-218, 1999. Pubmed reference: 10333259.
1998 Kelch, W.J., Smith, C.A., Lynn, R.C., New, J.C. :
Canine hypoadrenocorticism (Addisons-disease) Compendium on Continuing Education for the Practicing Veterinarian 20:921 ff., 1998.
Syme, H.M., Scottmoncrieff, J.C. :
Chronic hypoglycaemia in a hunting dog due to secondary hypoadrenocorticism Journal of Small Animal Practice 39:348-351, 1998. Pubmed reference: 9693421.
Vollmar, A., Hoppen, H.O., Ueberschar, S. :
Secondary hypoadrenocorticism in a 4 month old Irish Wolfhound [German] Kleintierpraxis 43:453 ff., 1998.
1997 Burton, S., Delay, J., Holmes, A., Somerville, C., Eye, J., Shaw, D., Wack, O., Hanna, P. :
Hypoadrenocorticism in young related Nova Scotia Duck Tolling Retrievers Canadian Veterinary Journal - Revue Veterinaire Canadienne 38:231-234, 1997.
Hirt, R., Kleiter, M. :
Hypoadrenocorticism - a diagnostic challenge [German] Kleintierpraxis 42:779 ff., 1997.
Kintzer, P.P., Peterson, M.E. :
Primary and secondary hypoadrenocorticism Veterinary Clinics of North America - Small Animal Practice 27:349 ff., 1997.
Kintzer, P.P., Peterson, M.E. :
Treatment and long-term follow-up of 205 dogs with hypoadrenocorticism Journal of Veterinary Internal Medicine 11:43-49, 1997. Pubmed reference: 9127289.
Koch, J., Jensen, A.L., Wenck, A., Iversen, L., Lykkegaard, K. :
Duplex doppler measurements of renal blood flow in a dog with addisons disease Journal of Small Animal Practice 38:124-126, 1997. Pubmed reference: 9097245.
1996 Lifton, S.J., King, L.G., Zerbe, C.A. :
Glucocorticoid deficient hypoadrenocorticism in dogs - 18 cases (1986-1995) Journal of the American Veterinary Medical Association 209:2076-2081, 1996. Pubmed reference: 8960190.
Melian, C., Peterson, M.E. :
Diagnosis and treatment of naturally occurring hypoadrenocorticism in 42 dogs Journal of Small Animal Practice 37:268-275, 1996. Pubmed reference: 8805097.
Peterson, M.E., Kintzer, P.P., Kass, P.H. :
Pretreatment clinical and laboratory findings in dogs with hypoadrenocorticism - 225 cases (1979-1993) Journal of the American Veterinary Medical Association 208:85-91, 1996. Pubmed reference: 8682712.
Sadek, D., Schaer, M. :
Atypical addisons disease in the dog - a retrospective survey of 14 cases Journal of the American Animal Hospital Association 32:159-163, 1996. Pubmed reference: 8680923.
1995 Dixon, R. :
The most common causes of hyperkalaemia in the dog are hypoadrenocorticism (Addison's disease), acute renal failure, and urethral obstruction Journal of Small Animal Practice 36:49, 1995. Pubmed reference: 7723288.
Langlaisburgess, L., Lumsden, J.H., Mackin, A. :
Concurrent hypoadrenocorticism and hypoalbuminemia in dogs Journal of the American Animal Hospital Association 31:307-311, 1995. Pubmed reference: 7552662.
1994 Boujon, C.E., Bornandjaunin, V., Scharer, V., Rossi, G.L., Bestetti, G.E. :
Pituitary gland changes in canine hypoadrenocorticism: A functional and immunocytochemical study Journal of Comparative Pathology 111:287-295, 1994. Pubmed reference: 7836570.
Kemppainen, R.J., Clark, T.P., Peterson, M.E. :
Preservative effect of aprotinin on canine plasma immunoreactive adrenocorticotropin concentrations Domestic Animal Endocrinology 11:355-362, 1994. Pubmed reference: 7530181.
Kintzer, P.P., Peterson, M.E. :
Diagnosis and Management of Primary Spontaneous Hypoadrenocorticism (Addison's Disease) in Dogs Seminars in Veterinary Medicine and Surgery - Small Animal 9:148-152, 1994. Pubmed reference: 7938935.
1993 Pascoe, K. :
Treatment of Hypoadrenocorticism in Dogs Journal of the American Veterinary Medical Association 202:1192-1193, 1993. Pubmed reference: 8496071.
1991 Volz, R. :
Primary Adrenocortical Insufficiency in the Dog, Addisons Disease - A Case Report Praktische Tierarzt 72:565-568, 1991.

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  • Created by Frank Nicholas on 06 Sep 2005