OMIA:000519-9796 : Hypoadrenocorticism in Equus caballus (horse)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: Hypoadrenocorticism, or Addison’s disease, results from insufficient secretion of steroid hormones (glucocorticoids and mineralocorticoids) from the adrenal glands. In primary hypoadrenocorticism the disease is due to changes to the adrenal cortex, while secondary hypoadrenocorticism refers to deficiency of ACTH, produced in the pituitary gland. The disease can be further classified as typical (glucocorticoid and mineralocorticoid deficiency) with typical electrolyte changes or atypical (only glucocorticoid deficiency with no typical electrolyte changes). The atypical cases often progress to become typical.
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
|1998||Couetil, L.L., Hoffman, A.M. :|
|Adrenal insufficiency in a neonatal foal Journal of the American Veterinary Medical Association 212:1594 ff., 1998.|
- Created by Frank Nicholas on 06 Sep 2005