OMIA:000536-9649 : Hypothyroidism, congenital in Ailurus fulgens (lesser panda)
Links to MONDO diseases:
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: Deficiency of thyroid gland activity. Also known as Goiterous congenital hypothyroidism; Congenital hypothyroidism; Thyroid dyshormonogenesis. This disorder can be caused by mutations in different genes, and forms of the disease exist that are not inherited.
Inheritance: Eustace et al. (2021): "Nongoitrous CH [congenital hypothyroidism] was presumptively diagnosed in 75% (n = 6/8) of red panda neonates from four successive litters, with a common sire and two closely related dams."
Have human generated variants been created, e.g. through genetic engineering and gene editing
Clinical features: Eustace et al. (2021): "Antemortem diagnosis of CH [congenital hypothyroidism] was made in three cubs (n = 3/6) based on elevated thyroid stimulating hormone and decreased free thyroxine and total thyroxine levels. Affected cubs also had suggestive clinical signs, which included delayed growth with cretinous dwarf appearance, atonic bladder, delayed gastrointestinal motility, hypercholesterolemia, and hypocalcemia."
Pathology: Eustace et al. (2021): "On necropsy cubs (n = 4) were small with varying degrees of cretin dwarf appearance and hypoplastic thyroids with reduced to no colloid in follicles."
Control: Eustace et al. (2021): "With sodium levothyroxine therapy, two of the three cubs developed into normal adult red pandas in terms of body size, appearance, and behavior."
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Eustace, R., Agnew, D., Fitzgerald, S.D., Fyfe, J.C., Duncan, A.E., Petroff, B., Thompson, K.A. :|
|PRESUMPTIVE CONGENITAL HYPOTHYROIDISM IN RED PANDAS (AILURUS FULGENS FULGENS) FROM FOUR SUCCESSIVE LITTERS. J Zoo Wildl Med 52:795-805, 2021. Pubmed reference: 34130428. DOI: 10.1638/2020-0122.|
|2015||Delaski, K.M., Ramsay, E., Gamble, K.C. :|
|RETROSPECTIVE ANALYSIS OF MORTALITY IN THE NORTH AMERICAN CAPTIVE RED PANDA (AILURUS FULGENS) POPULATION, 1992-2012. J Zoo Wildl Med 46:779-88, 2015. Pubmed reference: 26667534. DOI: 10.1638/2014-0166.1.|
- Created by Imke Tammen2 on 18 Jun 2021
- Changed by Imke Tammen2 on 18 Jun 2021
- Changed by Imke Tammen2 on 16 Oct 2023