OMIA 000536-9649 : Hypothyroidism, congenital in Ailurus fulgens

In other species: chicken , dog , domestic cat , horse , goat , sheep

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 274500 (trait) , 606765 (gene)

Mendelian trait/disorder: unknown

Considered a defect: unknown

Cross-species summary: Deficiency of thyroid gland activity. Also known as Goiterous congenital hypothyroidism; Congenital hypothyroidism; Thyroid dyshormonogenesis

Inheritance: Eustace et al. (2021): "Nongoitrous CH [congenital hypothyroidism] was presumptively diagnosed in 75% (n = 6/8) of red panda neonates from four successive litters, with a common sire and two closely related dams."

Clinical features: Eustace et al. (2021): "Antemortem diagnosis of CH [congenital hypothyroidism] was made in three cubs (n = 3/6) based on elevated thyroid stimulating hormone and decreased free thyroxine and total thyroxine levels. Affected cubs also had suggestive clinical signs, which included delayed growth with cretinous dwarf appearance, atonic bladder, delayed gastrointestinal motility, hypercholesterolemia, and hypocalcemia."

Pathology: Eustace et al. (2021): "On necropsy cubs (n = 4) were small with varying degrees of cretin dwarf appearance and hypoplastic thyroids with reduced to no colloid in follicles."

Control: Eustace et al. (2021): "With sodium levothyroxine therapy, two of the three cubs developed into normal adult red pandas in terms of body size, appearance, and behavior."

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Eustace, R., Agnew, D., Fitzgerald, S.D., Fyfe, J.C., Duncan, A.E., Petroff, B., Thompson, K.A. :
PRESUMPTIVE CONGENITAL HYPOTHYROIDISM IN RED PANDAS (AILURUS FULGENS FULGENS) FROM FOUR SUCCESSIVE LITTERS. J Zoo Wildl Med 52:795-805, 2021. Pubmed reference: 34130428. DOI: 10.1638/2020-0122.
2015 Delaski, K.M., Ramsay, E., Gamble, K.C. :
RETROSPECTIVE ANALYSIS OF MORTALITY IN THE NORTH AMERICAN CAPTIVE RED PANDA (AILURUS FULGENS) POPULATION, 1992-2012. J Zoo Wildl Med 46:779-88, 2015. Pubmed reference: 26667534. DOI: 10.1638/2014-0166.1.

Edit History


  • Created by Imke Tammen2 on 18 Jun 2021
  • Changed by Imke Tammen2 on 18 Jun 2021