OMIA 000536-9925 : Hypothyroidism, congenital in Capra hircus

In other species: domestic cat , chicken , dog , sheep , horse , lesser panda

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 274500 (trait) , 606765 (gene)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Deficiency of thyroid gland activity. Also known as Goiterous congenital hypothyroidism; Congenital hypothyroidism; Thyroid dyshormonogenesis. This disorder can be caused by mutations in different genes, and forms of the disease exist that are not inherited.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1997 Piosik, P.A., Vangroenigen, M., Vandoorn, J., Baas, F., Devijlder, J.J.M. :
Effects of maternal thyroid status on thyroid hormones and growth in congenitally hypothyroid goat fetuses during the second half of gestation Endocrinology 138:5-11, 1997. Pubmed reference: 8977378.
1996 Piosik, P.A., Vangroenigen, M., Baas, F. :
Effect of thyroid hormone deficiency on RC3/Neurogranin mRNA expression in the prenatal and adult caprine brain Molecular Brain Research 42:227-235, 1996. Pubmed reference: 9013778.
1995 Piosik, P.A., Vangroenigen, M., Ponne, N.J., Bolhuis, P.A., Baas, F. :
RC3 neurogranin structure and expression in the caprine brain in relation to congenital hypothyroidism Molecular Brain Research 29:119-130, 1995. Pubmed reference: 7539519.

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  • Created by Frank Nicholas on 06 Sep 2005