OMIA:000562-9913 : Infertility in Bos taurus (taurine cattle)

In other species: dog , pig , sheep , dzo

Categories: Reproductive system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 123885 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Cross-species summary: Inability to conceive. Has a wide variety of causes, some of which are at least partly genetic.

Markers: Arishima et al. (2017) "identified a maternal variant in the upstream region of FOXP3 [g.92,377,635A>G] that was associated with infertility in repeat-breeding Japanese Black cattle that failed to conceive using ET. The variant affected the level of FOXP3 mRNA expression. Thus, the results suggest that the risk-allele could serve as a useful marker to reduce and eliminate animals with inferior fertility in Japanese Black cattle."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000562-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Marrella, M.A., Biase, F.H. :
A multi-omics analysis identifies molecular features associated with fertility in heifers (Bos taurus). Sci Rep 13:12664, 2023. Pubmed reference: 37542054. DOI: 10.1038/s41598-023-39858-0.
Pausch, H., Mapel, X.M. :
Review: Genetic mutations affecting bull fertility. Animal 17 Suppl 1:100742, 2023. Pubmed reference: 37567657. DOI: 10.1016/j.animal.2023.100742.
Rho, N.Y., Mogas, T., King, W.A., Favetta, L.A. :
Testis-specific protein Y-encoded (TSPY) is required for male early embryo development in Bos taurus. Int J Mol Sci 24, 2023. Pubmed reference: 36834761. DOI: 10.3390/ijms24043349.
Sun, T., Pei, S., Liu, Y., Hanif, Q., Xu, H., Chen, N., Lei, C., Yue, X. :
Whole genome sequencing of simmental cattle for SNP and CNV discovery. BMC Genomics 24:179, 2023. Pubmed reference: 37020271. DOI: 10.1186/s12864-023-09248-x.
2019 Nakamura, Y., Iwata, H., Kuwayama, T., Shirasuna, K. :
S100A8, which increases with age, induces cellular senescence-like changes in bovine oviduct epithelial cells. Am J Reprod Immunol 82:e13163, 2019. Pubmed reference: 31237976. DOI: 10.1111/aji.13163.
2017 Arishima, T., Sasaki, S., Isobe, T., Ikebata, Y., Shimbara, S., Ikeda, S., Kawashima, K., Suzuki, Y., Watanabe, M., Sugano, S., Mizoshita, K., Sugimoto, Y. :
Maternal variant in the upstream of FOXP3 gene on the X chromosome is associated with recurrent infertility in Japanese Black cattle. BMC Genet 18:103, 2017. Pubmed reference: 29212449. DOI: 10.1186/s12863-017-0573-8.
1959 Calisti, V. :
Hereditary sterility in cattle Atti della Societa Italiana delle Scienze Veterinarie 13:51-136, 1959.
Ostrowski, J.E.B. :
[The transmission by bulls of hereditary diseases affecting fertility with special reference to anatomical defects of the genitalia. (A review.)] Veterinary Medicine Dissertation, Tieraliche Hochsch., Hanover :?, 1959.
1957 Csukas, Z. :
Genetic causes of sterility in cows Magyar Allatorvosok Lapja 12:38-40, 1957.
1956 Bauer, H. :
Proportion of bulls rejected because of infertility Proceedings of the Third International Congress of Animal Reproduction, Cambridge :77-79, 1956.
1955 Rollinson, D.H.L. :
Hereditary factors affecting reproductive efficiency in cattle Animal Breeding Abstracts 23:215-249, 1955.
1954 Kidwell, J.F., Walker, LeG., McCormick, J.A. :
Hereditary female sterility in Holstein Friesian cattle Journal of Heredity 45:142-145, 1954.
1951 Lagerlof, N. :
Hereditary forms of sterility in Swedish cattle breeds Fertility and Sterility 2:230-235, 1951. Pubmed reference: 14831646.
1949 Henle, C. :
Untersuchungen uber die Vererbung von Fruchtbarkeit und Unfruchtbarkeit beim Allgauer Rind [Heredity of fertility and sterility in Bavarian Allgauer cattle] Dissertation, Munich. From abstract in Zuchtungskunde 23:43-44, 1949.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 29 Nov 2011
  • Changed by Imke Tammen2 on 24 Aug 2022
  • Changed by Imke Tammen2 on 29 Apr 2023