OMIA:000562-9940 : Infertility in Ovis aries (sheep)
Categories: Reproductive system phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 123885 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: no
Mode of inheritance: Multifactorial
Considered a defect: yes
Key variant known: no
Cross-species summary: Inability to conceive. Has a wide variety of causes, some of which are at least partly genetic.
Molecular basis: Li et al. (2021) explored the impact of S100A8 on immune homeostasis in sheep oviduct epithelial cells (SOEC) as "Chronic inflammation can cause oviduct mucosal damage and immune dysfunction, leading to infertility, early pregnancy loss, ectopic pregnancy, tumors, and a decrease in reproductive capacities in female animals." Transcriptome analysis of differentially treated SOECs indicated S100A8 as a gene for further analysis in cultured cells: "The S100A8 gene was disrupted using the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 method .... S100A8 knockdown caused an excessive immune response, indicating that S100A8 is beneficial for maintaining immune homeostasis in the oviduct mucosa." (This study uses genome editing (GMO)). (Edited by Hannah Edgell 28/08/2022)
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|S100A8||S100 calcium binding protein A8||Ovis aries||1||NC_056054.1 (103771068..103770088)||S100A8||Homologene, Ensembl , NCBI gene|
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Li, X., Cao, G., Yang, H., Zhi, D., Li, L., Wang, D., Liu, M., Su, H. :|
|S100A8 expression in oviduct mucosal epithelial cells is regulated by estrogen and affects mucosal immune homeostasis. PLoS One 16:e0260188, 2021. Pubmed reference: 34793556 . DOI: 10.1371/journal.pone.0260188.|
|1952||Jakobiec, J. :|
|Inheritance of fertility in sheep Roczniki Nauk Rolniczych 62:177-198, 1952.|
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Imke Tammen2 on 24 Aug 2022