OMIA 000573-9615 : Kartagener syndrome in Canis lupus familiaris

In other species: domestic cat , pig

Possibly relevant human trait(s) and/or gene(s) (MIM number): 244400

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Key variant known: no

Cross-species summary: Congenital defect in functioning of the cilia, which are minute hair-like processes that extend from cell surfaces, beating ryhthmically to move fluid or mucous over the surface. The abnormal functioning results in bronchiectasis (chronic dilation of the bronchi and bronchioles, with associated infection) and sinusitis (inflammation of one or more of the paranasal sinuses). It is also associated with dextrocardia (location of the heart in the right side of the thorax, rather than the usual left side).

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2008 Cavrenne, R., De Busscher, V., Bolen, G., Billen, F., Clercx, C., Snaps, F. :
Primary ciliary dyskinesia and situs inversus in a young dog. Vet Rec 163:54-5, 2008. Pubmed reference: 18621999.
2004 De Scally, M., Lobetti, RG., Van Wilpe, E. :
Primary ciliary dyskinesia in a Staffordshire bull terrier. J S Afr Vet Assoc 75:150-2, 2004. Pubmed reference: 15628808.
2002 Neil, J.A., Canapp, S.O., Cook, C.R., Lattimer, J.C. :
Kartagener's syndrome in a Dachshund dog Journal of the American Animal Hospital Association 38:45-49, 2002. Pubmed reference: 11804314.
2000 Clercx, C., Peeters, D., Beths, T., McEntee, K., Votion, D., Snaps, F., Henroteaux, M., Jorissen, M. :
Use of ciliogenesis in the diagnosis of primary ciliary dyskinesia in a dog Journal of the American Veterinary Medical Association 217:1681-1685, 2000. Pubmed reference: 11110460.
1999 Watson, P.J., Herrtage, M.E., Peacock, M.A., Sargan, D.R. :
Primary ciliary dyskinesia in Newfoundland dogs Veterinary Record 144:718-+, 1999. Pubmed reference: 10423815.
1998 Watson, P.J., Herrtage, M.E., Sargan, D. :
Primary ciliary dyskinesia in Newfoundland dogs Veterinary Record 143:484, 1998. Pubmed reference: 9829312.
1994 Haller, M., Guscetti, F. :
Chronic Rhinosinusitis, Bronchitis and Situs-Inversus in 2 English Cocker-Spaniel Littermates - Primary Ciliary Dyskinesia? Kleintierpraxis 39:865-868, 1994.
1991 Maddux, J.M., Edwards, D.F., Barnhill, M.A., Sanders, W.L. :
Neutrophil Function in Dogs with Congenital Ciliary Dyskinesia Veterinary Pathology 28:347-353, 1991. Pubmed reference: 1750159.
1989 Edwards, D.F., Kennedy, J.R., Patton, C.S., Toal, R.L., Daniel, G.B., Lothrop, C.D. :
Familial Immotile-Cilia Syndrome in English Springer Spaniel Dogs American Journal of Medical Genetics 33:290-298, 1989. Pubmed reference: 2801763. DOI: 10.1002/ajmg.1320330303.
Edwards, D.F., Kennedy, J.R., Toal, R.L., Maddux, J.M., Barnhill, M.A., Daniel, G.B. :
Kartageners Syndrome in a Chow Chow Dog with Normal Ciliary Ultrastructure Veterinary Pathology 26:338-340, 1989. Pubmed reference: 2788326.

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  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 05 Aug 2013