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OMIA 000576-9913 : Knobbed acrosome in Bos taurus

In other species: pig , sheep , horse , dog

Possibly relevant human trait(s) and/or gene(s) (MIM number): 606165 (gene)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: The presence of a protrusion (knob) on the acrosome (cap) of a sperm. Associated with sterility. Also known as Knobbed Acrosome Defect (KAD)

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2005 Chenoweth, P.J. :
Genetic sperm defects. Theriogenology 64:457-68, 2005. Pubmed reference: 15993939. DOI: 10.1016/j.theriogenology.2005.05.005.
2002 Thundathil, J., Palasz, AT., Barth, AD., Mapletoft, RJ. :
Plasma membrane and acrosomal integrity in bovine spermatozoa with the knobbed acrosome defect. Theriogenology 58:87-102, 2002. Pubmed reference: 12182368.
2000 Thundathil, J., Meyer, R., Palasz, AT., Barth, AD., Mapletoft, RJ. :
Effect of the knobbed acrosome defect in bovine sperm on IVF and embryo production. Theriogenology 54:921-34, 2000. Pubmed reference: 11097045. DOI: 10.1016/S0093-691X(00)00402-7.
1985 Mitchell, JR., Senger, PL., Rosenberger, JL. :
Distribution and retention of spermatozoa with acrosomal and nuclear abnormalities in the cow genital tract. J Anim Sci 61:956-67, 1985. Pubmed reference: 4066546.
1983 Blom, E. :
The ultrastructure of some characteristic sperm defects and a proposal for a new classification of the bull spermiogram Nordisk Veterinary Medicine 25:383-391, 1983.
1976 Cran, D.G., Dott, H.M. :
The ultrastructure of knobbed bull spermatozoa Journal of Reproduction and Fertility 47:407-408, 1976. Pubmed reference: 957345.
1962 Blom, E., Birch-Andersen, A. :
Ultrastructure of the sterilizing 'knobbed-sperm' defect in the bull Nature 194:989-990, 1962.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 21 May 2012