OMIA 000576-9940 : Knobbed acrosome in Ovis aries

In other species: pig , cattle , horse , dog

Possibly relevant human trait(s) and/or gene(s) (MIM number): 606165 (gene)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: The presence of a protrusion (knob) on the acrosome (cap) of a sperm. Associated with sterility. Also known as Knobbed Acrosome Defect (KAD)

Species-specific description: There is no evidence for inheritance of this disorder in sheep. It is included here because a similar disorder appears to be inherited in pigs and cattle.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1998 Soderquist, L. :
Reduced fertility after artificial insemination in a ram with a high incidence of knobbed acrosomes Veterinary Record 143:227-228, 1998. Pubmed reference: 9770767.
1984 Savage, N.G. :
Infertility in a ram associated with a knobbed acrosome abnormality of the spermatozoa Canadian Veterinary Journal 25:126-127, 1984.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 21 May 2012