OMIA 000629 : Megacolon

Possible human homologues (MIM numbers): 600155 (trait) , 277580 (trait) , 600501 (trait) , 131244 (gene)

Cross-species summary: Also known as Hirschsprung disease. A disorder in which the large intestine (caecum, colon and sometimes the rectum) undergoes a large dilation and fills with faecal mass. Associated with incomplete migration of nerve cells to the intestine during embryonic development, resulting in lack of peristalsis and hence a build-up of faecal material.

Species in which this phene is found:
domestic cat (Felis catus)
horse (Equus caballus)
pig (Sus scrofa)
cattle (Bos taurus)
rabbit (Oryctolagus cuniculus)

Edit History

  • Created by Frank Nicholas on 20 Sep 2008
  • Changed by Frank Nicholas on 27 Jun 2013
  • Changed by Frank Nicholas on 26 Aug 2013
  • Changed by Imke Tammen2 on 10 Jul 2021
  • Changed by Imke Tammen2 on 25 Sep 2021