OMIA 000629-9823 : Megacolon in Sus scrofa

In other species: domestic cat , horse , rabbit , cattle

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 600155 (trait) , 277580 (trait) , 600501 (trait) , 131244 (gene)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Also known as Hirschsprung disease. A disorder in which the large intestine (caecum, colon and sometimes the rectum) undergoes a large dilation and fills with faecal mass. Associated with incomplete migration of nerve cells to the intestine during embryonic development, resulting in lack of peristalsis and hence a build-up of faecal material.

Inheritance: No good family data have been published for pigs. However, this disorder is single-locus in some other species.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2001 Stockhofe-Zurwieden, N., Buijs, R.M., De, Jong, M. :
Megacolon in pigs due to segmental colon aganglionosis Deutsche Tierarztliche Wochenschrift 108:267-269, 2001. Pubmed reference: 11449915.
1999 Bassett, J.R., Mann, F.A., Constantinescu, G.M., McClure, R.C. :
Subtotal colectomy and ileocolonic anastomosis in a Vietnamese pot-bellied pig with idiopathic megacolon Journal of the American Veterinary Medical Association 215:1640-+, 1999. Pubmed reference: 14567427.
1968 Osborne, J.C., Davis, J.W., Farley, H. :
Hirschsprung's disease: a review and report of the entity in a Virginia swine herd Veterinary Medicine and Small Animal Clinician 63:451-453, 1968. Pubmed reference: 5184921.
1955 Kernkamp, H.C.H., Kanning, H.H. :
Primary megacolon (Hirschsprung's disease) in swine North American Veterinarian 36:642-643, 1955.

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  • Created by Frank Nicholas on 06 Sep 2005