OMIA 000629-9913 : Megacolon in Bos taurus

In other species: domestic cat , horse , pig , rabbit

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 600155 (trait) , 277580 (trait) , 600501 (trait) , 131244 (gene)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Also known as Hirschsprung disease. A disorder in which the large intestine (caecum, colon and sometimes the rectum) undergoes a large dilation and fills with faecal mass. Associated with incomplete migration of nerve cells to the intestine during embryonic development, resulting in lack of peristalsis and hence a build-up of faecal material.


2005 Forzán, M.J., McClure, J.T. :
Congenital aganglionosis in a 3-day-old Holstein calf. Can Vet J 46:342-4, 2005. Pubmed reference: 15943121.

Edit History

  • Created by Frank Nicholas on 18 Sep 2005