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OMIA:000629-9913 : Megacolon in Bos taurus (taurine cattle)

In other species: domestic cat , horse , pig , rabbit

Categories: Digestive / alimentary phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 600155 (trait) , 277580 (trait) , 600501 (trait) , 131244 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Also known as Hirschsprung disease. A disorder in which the large intestine (caecum, colon and sometimes the rectum) undergoes a large dilation and fills with faecal mass. Associated with incomplete migration of nerve cells to the intestine during embryonic development, resulting in lack of peristalsis and hence a build-up of faecal material.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:000629-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2005 Forzán, M.J., McClure, J.T. :
Congenital aganglionosis in a 3-day-old Holstein calf. Can Vet J 46:342-4, 2005. Pubmed reference: 15943121.

Edit History


  • Created by Frank Nicholas on 18 Sep 2005