OMIA:000629-9913 : Megacolon in Bos taurus (taurine cattle)
Categories: Digestive / alimentary phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: Also known as Hirschsprung disease. A disorder in which the large intestine (caecum, colon and sometimes the rectum) undergoes a large dilation and fills with faecal mass. Associated with incomplete migration of nerve cells to the intestine during embryonic development, resulting in lack of peristalsis and hence a build-up of faecal material.
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
|2005||Forzán, M.J., McClure, J.T. :|
|Congenital aganglionosis in a 3-day-old Holstein calf. Can Vet J 46:342-4, 2005. Pubmed reference: 15943121.|
- Created by Frank Nicholas on 18 Sep 2005