OMIA 000631-9615 : Megaoesophagus in Canis lupus familiaris

In other species: domestic cat , sheep , domestic ferret , llama , goat , cattle , horse

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Dilatation and atony of the body of the oesophagus, usually associated with asynchronous function of the oesophagus and the caudal oesophageal sphincter. Causes regurgitation and aspiration pneumonia.

Mapping: By conducting a GWAS on 19 affected and 177 control German Shepherd dogs, each genotyped with the Affymetrix v2 canine SNP chip (Yielding 48,415 SNPs for the analysis), Tsai et al. (2012) highlighted a 4.7Mb region on chromosome CFA12.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2016 Manning, K., Birkenheuer, A.J., Briley, J., Montgomery, S.A., Harris, J., Vanone, S.L., Gookin, J.L. :
Intermittent At-Home Suctioning of Esophageal Content for Prevention of Recurrent Aspiration Pneumonia in 4 Dogs with Megaesophagus. J Vet Intern Med :, 2016. Pubmed reference: 27481487. DOI: 10.1111/jvim.14527.
2012 Mace, S., Shelton, G.D., Eddlestone, S. :
Megaesophagus. Compend Contin Educ Vet 34:E1, 2012. Pubmed reference: 22488663.
Tsai, K.L., Noorai, R.E., Starr-Moss, A.N., Quignon, P., Rinz, C.J., Ostrander, E.A., Steiner, J.M., Murphy, K.E., Clark, L.A. :
Genome-wide association studies for multiple diseases of the German Shepherd Dog. Mamm Genome 23:203-11, 2012. Pubmed reference: 22105877. DOI: 10.1007/s00335-011-9376-9.
2002 Watrous, B.J., Blumenfeld, B. :
Congenital megaesophagus with hypertrophic osteopathy in a 6-year-old dog Veterinary Radiology & Ultrasound 43:545-549, 2002. Pubmed reference: 12502108.
2001 Hopper, K., Beck, C., Slocombe, R. :
Megaoesophagus in adult dogs secondary to Australian tiger snake envenomation Australian Veterinary Journal 79:672-675, 2001. Pubmed reference: 11712704.
Huber, E., Armbrust, W., Forster, J.L., Ribiere, T., Grosclaude, P. :
Megaoesophagus in the dog: a case report Schweizer Archiv fur Tierheilkunde 143:512-514, 2001. Pubmed reference: 11680912.
2000 Torres, P. :
Esophagus-diaphragmatic Cardioplasty for the treatment of the idiopathic congenital total megaesophagus in dogs [Spanish] Archivos de Medicina Veterinaria 32:121-130, 2000.
1999 Plotnick, A.N. :
Megaesophagus and hypothyroidism in an English Springer Spaniel and response to thyroxine supplementation Canine Practice 24:14-17, 1999.
Rossmeisl, J.H., Blevins, W.E., Widmer, W.R. :
What is your diagnosis? Diagnosis - Radiographic diagnosis - Megaesophagus and gastrointestinal atony Journal of the American Veterinary Medical Association 215:782-+, 1999. Pubmed reference: 10496127.
1997 Borbe, J., Walla, L. :
Surgical and postoperative management of canine megaesophagus [German] Kleintierpraxis 42:329-332, 1997.
Gaynor, A.R., Shofer, F.S., Washabau, R.J. :
Risk factors for acquired megaesophagus in dogs Journal of the American Veterinary Medical Association 211:1406 ff., 1997.
Mears, E.A., Jenkins, C.C. :
Canine and feline megaesophagus Compendium on Continuing Education for the Practicing Veterinarian 19:313 ff., 1997.
Torres, P. :
Megaesophagus in the dog - a bibliographic review and a new classification proposal [Review] [Spanish] Archivos de Medicina Veterinaria 29:13-23, 1997.
1996 Holland, C.T., Satchell, P.M., Farrow, B.R.H. :
Vagal esophagomotor nerve function and esophageal motor performance in dogs with congenital idiopathic megaesophagus American Journal of Veterinary Research 57:906-913, 1996. Pubmed reference: 8725822.
1995 Whitley, N.T. :
Megaoesophagus and glucocorticoid-deficient hypoadrenocorticism in a dog Journal of Small Animal Practice 36:132-135, 1995. Pubmed reference: 7783439.
1994 Holland, C.T., Shelton, G.D., Satchell, P.M., Farrow, B.R.H. :
Antibodies to Nicotinic Acetylcholine Receptors in Dogs with Megaoesophagus Australian Veterinary Journal 71:221-222, 1994. Pubmed reference: 7945104.
Matros, L., Jergens, A.E., Miles, K.G., Kluge, J.P. :
Megaesophagus and Hypomotility Associated with Esophageal Leiomyoma in a Dog Journal of the American Animal Hospital Association 30:15-19, 1994.
Thilagar, S., Balasubramanian, N.N., David, W.P.A., Sasikala, S. :
A Clinical Survey of Megaesophagus in the Dog Indian Veterinary Journal 71:921-922, 1994.
1993 Holland, C.T., Satchell, P.M., Farrow, B.R.H. :
Oesophageal Compliance in Naturally Occurring Canine Megaoesophagus Australian Veterinary Journal 70:414-420, 1993. Pubmed reference: 8280024.
Holland, C.T., Satchell, P.M. :
Megaoesophagus in the Dog and Cat Recueil de Medecine Veterinaire 169:969-983, 1993.
1990 Knowles, K.E., Obrien, D.P., Amann, J.F. :
Congenital Idiopathic Megaesophagus in a Litter of Chinese Shar-Peis - Clinical, Electrodiagnostic, and Pathological Findings Journal of the American Animal Hospital Association 26:313-318, 1990.
1957 Michael, S.J. :
Regurgitation in pups. II. Megaesophagus in a pup Journal of the American Veterinary Medical Association 130:284 only, 1957. Pubmed reference: 13416103.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 20 May 2013