OMIA 000754-9913 : Osteogenesis imperfecta, generic in Bos taurus

In other species: domestic cat , dog , sheep

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 166210 , 166220 , 259420

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Cross-species summary: Abnormally brittle bones that fracture easily.

Inheritance: By genome sequencing an affected an affected male Holstein calf and its parents, Zhang et al. (2020) were not able to identify a single likely causal variant, and concluded that this particular form of osteogenesis imperfecta is oligogenic, i.e. multifactorial.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Zhang, X., Hirschfeld, M., Beck, J., Kupke, A., Köhler, K., Schütz, E., Brenig, B. :
Osteogenesis imperfecta in a male Holstein calf associated with a possible oligogenic origin. Vet Q :1-14, 2020. Pubmed reference: 31980012. DOI: 10.1080/01652176.2020.1721611.
1994 Agerholm, JS., Lund, AM., Bloch, B., Reibel, J., Basse, A., Arnbjerg, J. :
Osteogenesis imperfecta in Holstein-Friesian calves. Zentralbl Veterinarmed A 41:128-38, 1994. Pubmed reference: 8091888.
1993 Agerholm, J.S., Basse, A., Christensen, K. :
Investigations on the occurrence of hereditary diseases in the Danish cattle population 1989-1991 Acta Veterinaria Scandinavica 34:245-253, 1993. Pubmed reference: 8310897.
1987 Fisher, LW., Eanes, ED., Denholm, LJ., Heywood, BR., Termine, JD. :
Two bovine models of osteogenesis imperfecta exhibit decreased apatite crystal size. Calcif Tissue Int 40:282-5, 1987. Pubmed reference: 3107782.
1986 Fisher, LW., Denholm, LJ., Conn, KM., Termine, JD. :
Mineralized tissue protein profiles in the Australian form of bovine osteogenesis imperfecta. Calcif Tissue Int 38:16-20, 1986. Pubmed reference: 3079647.
1984 Termine, JD., Robey, PG., Fisher, LW., Shimokawa, H., Drum, MA., Conn, KM., Hawkins, GR., Cruz, JB., Thompson, KG. :
Osteonectin, bone proteoglycan, and phosphophoryn defects in a form of bovine osteogenesis imperfecta. Proc Natl Acad Sci U S A 81:2213-7, 1984. Pubmed reference: 6585794.
1983 Denholm, LJ., Cole, WG. :
Heritable bone fragility, joint laxity and dysplastic dentin in Friesian calves: a bovine syndrome of osteogenesis imperfecta. Aust Vet J 60:9-17, 1983. Pubmed reference: 6830550.
1976 Jensen, P.T., Rusmussen, P.G., Basse, A. :
Congenital osteogenesis imperfecta in Charolais cattle Nordisk Veterinaermedicin 28:304-308, 1976. Pubmed reference: 940738.

Edit History


  • Created by Frank Nicholas on 30 Jun 2006
  • Changed by Frank Nicholas on 27 Jan 2020