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OMIA:000823-9796 : Prognathism in Equus caballus

In other species: cattle , dog , ass

Categories: Skeleton phene (incl. short stature & teeth)

Possibly relevant human trait(s) and/or gene(s) (MIM number): 176700 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: abnormal protrusion of the mandible

Mapping: From a GWAS on 96 affected and 763 non-affected controls, each genotyped with the Illumina Equine 50K SNP BeadChip (yielding 38,124 informative SNPs), Signer-Hasler et al. (2014) identified a candidate region "on the distal end of chromosome ECA 13" in which there appeared to be no obvious candidate gene.

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2017 Lauper, M., Gerber, V., Ramseyer, A., Burger, D., Lüth, A., Koch, C., Dolf, G. :
Heritabilities of health traits in Swiss Warmblood horses. Equine Vet J 49:15-18, 2017. Pubmed reference: 26538098 . DOI: 10.1111/evj.12537.
2014 Signer-Hasler, H., Neuditschko, M., Koch, C., Froidevaux, S., Flury, C., Burger, D., Leeb, T., Rieder, S. :
A chromosomal region on ECA13 is associated with maxillary prognathism in horses. PLoS One 9:e86607, 2014. Pubmed reference: 24466169 . DOI: 10.1371/journal.pone.0086607.
2007 Mele, M., Gerber, V., Straub, R., Gaillard, C., Jallon, L., Burger, D. :
Erhebung der Prävalenz von Erbkrankheiten bei dreijährigen Pferden der Freiberger-Rasse. [Prevalence of hereditary diseases in three-year-old franches-montagnes horses] Schweiz Arch Tierheilkd 149:151-159, 2007.
Studer, S., Gerber, V., Straub, R., Brehm, W., Gaillard, C., Lüth, A., Burger, D. :
Erhebung der Prävalenz von Erbkrankheiten bei dreijährigen Schweizer Warmblutpferden [Prevalence of hereditary diseases in three-year-old Swiss Warmblood horses] Schweiz Arch Tierheilkd 149:161-171, 2007.

Edit History


  • Created by Frank Nicholas on 29 Jan 2014
  • Changed by Frank Nicholas on 29 Jan 2014