OMIA 000991-9685 : Androgen insensitivity syndrome (AIS) in Felis catus
Edited by Vicki N. Meyers-Wallen, VMD, PhD, Dipl. ACTInheritance: As the AR is located on the X chromosome, XY males having one copy of the mutant AR are affected. Female carriers are heterozygous. Mapping: FCX Clinical features: Affected cats appear to be phenotypically normal females, but fail to exhibit estrous cycles at the age of puberty (primary anesrus). Affected cats have a male karyotype (38,XY) and undescended testes, but no other male or female reproductive organs are found internally (Meyers-Wallen et al., 1989). Pathology: As the androgen receptor is nonfunctional, the testosterone signaling pathway is interrupted, which causes complete failure of androgen-dependent masculinization in the internal and external genitalia. Affected cats lack epididymides and vasa deferentia and develop labia, a clitoris and a blind-ending caudal vagina. As the testes produce Müllerian inhibiting substance as expected, the Müllerian duct system regresses normally, causing absence of the oviducts, uterus, and cranial vagina (Meyers-Wallen et al., 1989). Prevalence: Rare Control: Further breeding of the dam of the affected cat is not recommended. Genetic testing: Cats can be tested for a qualitative or quantitative defect in the androgen receptor by testing androgen binding in genital fibroblasts (Meyers-Wallen et al., 1989). Breed: Domestic Shorthair.
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|1993||Meyers-Wallen, V.N. :|
|Genetics of Sexual Differentiation and Anomalies in Dogs and Cats Journal of Reproduction and Fertility :441-452, 1993. Pubmed reference: 8229960.|
|1989||Lawhorn, B. :|
|Testicular Feminization in a Cat Journal of the American Veterinary Medical Association 195:1456, 1989. Pubmed reference: 2599922.|
|Meyers-Wallen, V.N., Wilson, J.D., Griffin, J.E., Fisher, S., Moorhead, P.H., Goldschmidt, M.H., Haskins, M.E., Patterson, D.F. :|
|Testicular feminization in a cat. J Am Vet Med Assoc 195:631-4, 1989. Pubmed reference: 2777713.|
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Martha MaloneyHuss on 06 Sep 2011
- Changed by Frank Nicholas on 07 Sep 2011