OMIA:001142-9615 : Wilms tumour in Canis lupus familiaris

In other species: pig , cattle , sheep

Categories: Neoplasm

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 194070 (trait) , 194071 (trait) , 194072 (trait) , 194080 (trait) , 194090 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A rapidly developing malignant mixed tumour of the kidneys. The Wilms' tumour gene in human and mouse was cloned in the early 1990s. Since its peptide is involved in the development of the urinary-genital tract and the gonads, the gene is of considerable interest in relation to the genetic basis of sexual development. As described in the species summaries, the gene has been amplified by PCR in sheep, cattle and pig, and has been mapped in cattle and sheep. Future studies of this gene should shed interesting light on sexual development, and hence on the occurrence of abnormalities of sexual development in domestic animal species.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

1997 Pearson, G.R., Gregory, S.P., Charles, A.K. :
Immunohistochemical demonstration of wilms tumour gene product WT1 in a canine neuroepithelioma providing evidence for its classification as an extrarenal nephroblastoma Journal of Comparative Pathology 116:321-327, 1997. Pubmed reference: 9147249 .
1996 Shibuya, H., Collins, B.K., Collier, L.L., Huang, T.H.M., Nonneman, D., Johnson, G.S. :
A polymorphic (GAAA)(n) microsatellite in a canine Wilms tumor 1 (WT1) gene intron Animal Genetics 27:59-60, 1996. Pubmed reference: 8624042 .

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  • Created by Frank Nicholas on 06 Sep 2005