OMIA 001142-9823 : Wilms tumour in Sus scrofa

In other species: dog , cattle , sheep

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 194070 , 194071 , 194072 , 194080 , 194090

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A rapidly developing malignant mixed tumour of the kidneys. The Wilms' tumour gene in human and mouse was cloned in the early 1990s. Since its peptide is involved in the development of the urinary-genital tract and the gonads, the gene is of considerable interest in relation to the genetic basis of sexual development. As described in the species summaries, the gene has been amplified by PCR in sheep, cattle and pig, and has been mapped in cattle and sheep. Future studies of this gene should shed interesting light on sexual development, and hence on the occurrence of abnormalities of sexual development in domestic animal species.

Species-specific description: In 1995, Vaiman et al. designed conserved primers from mouse and human sequence data, and successfully amplified a 150-bp fragment of the homologous gene in pig, cattle and sheep, which includes a dinucleotide (TG) microsatellite.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1995 Vaiman, D., Pailhoux, E., Payen, E., Saidimehtar, N., Cotinot, C. :
Evolutionary conservation of a microsatellite in the Wilms Tumour (WT) gene: Mapping in sheep and cattle Cytogenetics and Cell Genetics 70:112-115, 1995. Pubmed reference: 7736774.
1992 Kushner, L., Cozzolino, A., Sherman, J., Rich, M.A. :
Expression of a Wilms Tumor Gene in Porcine Kidney During Compensatory Renal Growth Journal of Urology 148:555-558, 1992. Pubmed reference: 1640521.

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  • Created by Frank Nicholas on 06 Sep 2005