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OMIA 001258-9615 : Obesity in Canis lupus familiaris

In other species: pig , rabbit

Possibly relevant human trait(s) and/or gene(s) (MIM number): 164160

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Molecular basis: Raffan et al. (2016) reported that "Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation"

Breed: Labrador Retriever.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
POMC proopiomelanocortin Canis lupus familiaris 17 NC_006599.3 (19438247..19431396) POMC Homologene, Ensembl, NCBI gene

Variants

By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Labrador Retriever Obesity POMC deletion, small (<=20) CanFam3.1 17 g.19431807_19431821del p.E188fs 2016 27157046
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References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2017 Mankowska, M., Krzeminska, P., Graczyk, M., Switonski, M. :
Confirmation that a deletion in the POMC gene is associated with body weight of Labrador Retriever dogs. Res Vet Sci 112:116-118, 2017. Pubmed reference: 28235700. DOI: 10.1016/j.rvsc.2017.02.014.
2016 Raffan, E., Dennis, R.J., O'Donovan, C.J., Becker, J.M., Scott, R.A., Smith, S.P., Withers, D.J., Wood, C.J., Conci, E., Clements, D.N., Summers, K.M., German, A.J., Mellersh, C.S., Arendt, M.L., Iyemere, V.P., Withers, E., Söder, J., Wernersson, S., Andersson, G., Lindblad-Toh, K., Yeo, G.S., O'Rahilly, S. :
A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. Cell Metab 23:893-900, 2016. Pubmed reference: 27157046. DOI: 10.1016/j.cmet.2016.04.012.

Edit History


  • Created by Frank Nicholas on 19 May 2016
  • Changed by Frank Nicholas on 19 May 2016
  • Changed by Frank Nicholas on 19 Dec 2017