OMIA 001258-9615 : Obesity in Canis lupus familiaris |
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
POMC | proopiomelanocortin | Canis lupus familiaris | 17 | NC_051821.1 (19713398..19706608) | POMC | Homologene, Ensembl, NCBI gene |
Variants
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Source of Genetic Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Inferred EVA rsID | Year Published | PubMed ID(s) | Acknowledgements |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
809 | Labrador Retriever | Obesity | POMC | deletion, small (<=20) | Naturally occurring variant | CanFam3.1 | 17 | g.19431807_19431821del | c.561_575del | p.(E188fs) | XM_844370.3 | 2016 | 27157046 |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 | Ronja, N., Kölle, P. : | |
Adipositas beim Hund – ein Überblick zu den Ursachen [Obesity in dogs - A review of underlying reasons]. Tierarztl Prax Ausg K Kleintiere Heimtiere 49:284-293, 2021. Pubmed reference: 34425607. DOI: 10.1055/a-1548-2293. | ||
2020 | Wallis, N., Raffan, E. : | |
The genetic basis of obesity and related metabolic diseases in humans and companion animals. Genes 11:1378, 2020. Pubmed reference: 33233816. DOI: 10.3390/genes11111378. | ||
2017 | Davison, L.J., Holder, A., Catchpole, B., O'Callaghan, C.A. : | |
The canine POMC gene, obesity in Labrador Retrievers and susceptibility to diabetes mellitus. J Vet Intern Med 31:343-348, 2017. Pubmed reference: 28176381. DOI: 10.1111/jvim.14636. | ||
Mankowska, M., Krzeminska, P., Graczyk, M., Switonski, M. : | ||
Confirmation that a deletion in the POMC gene is associated with body weight of Labrador Retriever dogs. Res Vet Sci 112:116-118, 2017. Pubmed reference: 28235700. DOI: 10.1016/j.rvsc.2017.02.014. | ||
Mankowska, M., Nowacka-Woszuk, J., Graczyk, A., Ciazynska, P., Stachowiak, M., Switonski, M. : | ||
Polymorphism and methylation of the MC4R gene in obese and non-obese dogs. Mol Biol Rep 44:333-339, 2017. Pubmed reference: 28755272. DOI: 10.1007/s11033-017-4114-3. | ||
2016 | Raffan, E., Dennis, R.J., O'Donovan, C.J., Becker, J.M., Scott, R.A., Smith, S.P., Withers, D.J., Wood, C.J., Conci, E., Clements, D.N., Summers, K.M., German, A.J., Mellersh, C.S., Arendt, M.L., Iyemere, V.P., Withers, E., Söder, J., Wernersson, S., Andersson, G., Lindblad-Toh, K., Yeo, G.S., O'Rahilly, S. : | |
A deletion in the canine POMC gene is associated with weight and appetite in obesity-prone Labrador Retriever dogs. Cell Metab 23:893-900, 2016. Pubmed reference: 27157046. DOI: 10.1016/j.cmet.2016.04.012. |
Edit History
- Created by Frank Nicholas on 19 May 2016
- Changed by Frank Nicholas on 19 May 2016
- Changed by Frank Nicholas on 19 Dec 2017
- Changed by Frank Nicholas on 04 Mar 2020
- Changed by Frank Nicholas on 27 Jan 2021
- Changed by Imke Tammen2 on 26 Aug 2021