OMIA 001258-9615 : Obesity in Canis lupus familiaris |
In other species:
pig
,
rabbit
Possibly relevant human trait(s) and/or gene(s) (MIM number):
164160
Mendelian trait/disorder:
no
Mode of inheritance:
Multifactorial
Considered a defect:
yes
Key variant known:
no
Molecular basis:
Raffan et al. (2016) reported that "Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation"
Breed:
Labrador Retriever.
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| POMC | proopiomelanocortin | Canis lupus familiaris | 17 | NC_006599.3 (19438247..19431396) | POMC | Homologene, Ensembl, NCBI gene |
Variants
By default, variants are sorted chronologically by year of publication, to provide a historical perspective.
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| Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Year Published | PubMed ID(s) | Acknowledgements |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Labrador Retriever | Obesity | POMC | deletion, small (<=20) | CanFam3.1 | 17 | g.19431807_19431821del | p.E188fs | 2016 | 27157046 |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2017 | Mankowska, M., Krzeminska, P., Graczyk, M., Switonski, M. : | |
| Confirmation that a deletion in the POMC gene is associated with body weight of Labrador Retriever dogs. Res Vet Sci 112:116-118, 2017. Pubmed reference: 28235700. DOI: 10.1016/j.rvsc.2017.02.014. | ||
| 2016 | Raffan, E., Dennis, R.J., O'Donovan, C.J., Becker, J.M., Scott, R.A., Smith, S.P., Withers, D.J., Wood, C.J., Conci, E., Clements, D.N., Summers, K.M., German, A.J., Mellersh, C.S., Arendt, M.L., Iyemere, V.P., Withers, E., Söder, J., Wernersson, S., Andersson, G., Lindblad-Toh, K., Yeo, G.S., O'Rahilly, S. : | |
| A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. Cell Metab 23:893-900, 2016. Pubmed reference: 27157046. DOI: 10.1016/j.cmet.2016.04.012. |
Edit History
- Created by Frank Nicholas on 19 May 2016
- Changed by Frank Nicholas on 19 May 2016
- Changed by Frank Nicholas on 19 Dec 2017