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OMIA 001258-9823 : Obesity in Sus scrofa

In other species: dog , domestic cat , horse , rabbit

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 164160 (gene) , 614962 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Zhu et al. (2020) used CRISPR/Cas9 technology to knock out the iroquois homeobox 3 (IRX3) gene, which is implicated in human obesity, in Bama minipigs. However, "use of IRX3-/- cells as donor cells for the production of somatic cell-cloned pigs results in a significant decrease in the average live litter size and a significant increase in the average number of stillbirths. Moreover, the birth weight of surviving IRX3-/- somatic cell-cloned pigs is significantly lower, and viability is poor such that all piglets die shortly after birth. ... IRX3 should not be used as a gene editing target to reduce fat content ..."

This phene includes references to studies involving genetically modified organisms (GMO).

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2022 Bergen, W.G. :
Pigs (Sus scrofa) in biomedical research. Adv Exp Med Biol 1354:335-343, 2022. Pubmed reference: 34807450. DOI: 10.1007/978-3-030-85686-1_17.
Tu, C.F., Chuang, C.K., Yang, T.S. :
The application of new breeding technology based on gene editing in pig industry. Anim Biosci :, 2022. Pubmed reference: 34991204. DOI: 10.5713/ab.21.0390.
2021 Zhang, Y., Fan, G., Liu, X., Skovgaard, K., Sturek, M., Heegaard, P.M.H. :
The genome of the naturally evolved obesity-prone Ossabaw miniature pig. iScience 24:103081, 2021. Pubmed reference: 34585119. DOI: 10.1016/j.isci.2021.103081.
2020 Zhu, X., Wei, Y., Zhan, Q., Yan, A., Feng, J., Liu, L., Tang, D. :
CRISPR/Cas9-mediated biallelic knockout of IRX3 reduces the production and survival of somatic cell-cloned Bama minipigs. Animals (Basel) 10:501, 2020. Pubmed reference: 32192102. DOI: 10.3390/ani10030501.
1996 Neuenschwander, S., Rettenberger, G., Meijerink, E., Jorg, H., Stranzinger, G. :
Partial characterization of porcine obesity gene (obs) and its localization to chromosome 18 by somatic cell hybrids Animal Genetics 27:275-278, 1996. Pubmed reference: 8856925.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 11 Jan 2022