OMIA:001258-9823 : Obesity in Sus scrofa (pig)

In other species: crab-eating macaque , dog , domestic cat , horse , rabbit

Categories: Adipose tissue phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 164160 (gene) , 614962 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Zhu et al. (2020) used CRISPR/Cas9 technology to knock out the iroquois homeobox 3 (IRX3) gene, which is implicated in human obesity, in Bama minipigs. However, "use of IRX3-/- cells as donor cells for the production of somatic cell-cloned pigs results in a significant decrease in the average live litter size and a significant increase in the average number of stillbirths. Moreover, the birth weight of surviving IRX3-/- somatic cell-cloned pigs is significantly lower, and viability is poor such that all piglets die shortly after birth. ... IRX3 should not be used as a gene editing target to reduce fat content ..." This phene includes references to studies involving genetically modified organisms (GMO).

Genetic engineering: Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001258-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2022 Bergen, W.G. :
Pigs (Sus scrofa) in biomedical research. Adv Exp Med Biol 1354:335-343, 2022. Pubmed reference: 34807450. DOI: 10.1007/978-3-030-85686-1_17.
Tu, C.F., Chuang, C.K., Yang, T.S. :
The application of new breeding technology based on gene editing in pig industry - A review. Anim Biosci 35:791-803, 2022. Pubmed reference: 34991204. DOI: 10.5713/ab.21.0390.
2021 Zhang, Y., Fan, G., Liu, X., Skovgaard, K., Sturek, M., Heegaard, P.M.H. :
The genome of the naturally evolved obesity-prone Ossabaw miniature pig. iScience 24:103081, 2021. Pubmed reference: 34585119. DOI: 10.1016/j.isci.2021.103081.
2020 Zhu, X., Wei, Y., Zhan, Q., Yan, A., Feng, J., Liu, L., Tang, D. :
CRISPR/Cas9-mediated biallelic knockout of IRX3 reduces the production and survival of somatic cell-cloned Bama minipigs. Animals (Basel) 10:501, 2020. Pubmed reference: 32192102. DOI: 10.3390/ani10030501.
1996 Neuenschwander, S., Rettenberger, G., Meijerink, E., Jorg, H., Stranzinger, G. :
Partial characterization of porcine obesity gene (obs) and its localization to chromosome 18 by somatic cell hybrids Animal Genetics 27:275-278, 1996. Pubmed reference: 8856925.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 11 Jan 2022
  • Changed by Imke Tammen2 on 18 Dec 2023