OMIA:001258-9685 : Obesity in Felis catus (domestic cat)

In other species: crab-eating macaque , dog , horse , pig , rabbit

Categories: Adipose tissue phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 164160 (gene) , 614962 (trait)

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Molecular basis: Forcada et al. (2013) investigated the comparative and functional candidate gene MC4R in domestic shorthair cats. The authors identified a MC4R:c.92C>T variant in the gene and investigated an association with diabetes mellitus and overweight body condition score: "No significant differences in MC4R:c.92C>T allele or genotype frequencies were identified between nondiabetic overweight and lean cats." The association with the variant and overweight diabetic cats was significant (see OMIA:000284-9685 : Diabetes mellitus, type II in Felis catus). Jerjen et al. (2023) "assess the association between the previously described MC4R variant and body condition score (BCS), as well as body fat content (%BF) in 89 non-diabetic domestic shorthair cats. Furthermore, we investigated the feline POMC gene as a potential candidate gene for obesity. Our results indicate that the MC4R:c.92C>T polymorphism is not associated with BCS or %BF in non-diabetic domestic shorthair cats. The mutation analysis of all POMC exons identified two missense variants, with a variant in exon 1 (c.28G>C; p.G10R) predicted to be damaging. The variant was subsequently assessed in all 89 cats, and cats heterozygous for the variant had a significantly increased body condition score (p= 0.03) compared with cats homozygous for the wild-type allele."

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001258-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Jerjen, C.P., Kumaran, S.J., Liesegang, A., Hall, E., Wichert, B., Haase, B. :
Melanocortin-4 receptor and proopiomelanocortin: Candidate genes for obesity in domestic shorthair cats. Anim Genet , 2023. Pubmed reference: 37365843. DOI: 10.1111/age.13335.
O'Neill, D.G., Gunn-Moore, D., Sorrell, S., McAuslan, H., Church, D.B., Pegram, C., Brodbelt, D.C. :
Commonly diagnosed disorders in domestic cats in the UK and their associations with sex and age. J Feline Med Surg 25:1098612X231155016, 2023. Pubmed reference: 36852509. DOI: 10.1177/1098612X231155016.
2021 Alhaddad, H., Abdi, M., Lyons, L.A. :
Patterns of allele frequency differences among domestic cat breeds assessed by a 63K SNP array. PLoS One 16:e0247092, 2021. Pubmed reference: 33630878. DOI: 10.1371/journal.pone.0247092.
2020 Wallis, N., Raffan, E. :
The genetic basis of obesity and related metabolic diseases in humans and companion animals. Genes 11:1378, 2020. Pubmed reference: 33233816. DOI: 10.3390/genes11111378.
2013 Forcada, Y., Holder, A., Church, D.B., Catchpole, B. :
A polymorphism in the Melanocortin 4 Receptor Gene (MC4R:c.92C>T) is associated with diabetes mellitus in overweight domestic shorthaired cats. J Vet Intern Med , 2013. Pubmed reference: 24372947. DOI: 10.1111/jvim.12275.
2011 Häring, T., Wichert, B., Dolf, G., Haase, B. :
Segregation analysis of overweight body condition in an experimental cat population. J Hered 102 Suppl 1:S28-31, 2011. Pubmed reference: 21846744. DOI: 10.1093/jhered/esr029.

Edit History

  • Created by Imke Tammen2 on 02 Dec 2020
  • Changed by Imke Tammen2 on 28 Jun 2023
  • Changed by Imke Tammen2 on 12 Oct 2023