OMIA 001402-9685 : Multidrug resistance 1 in Felis catus
Mealey et al. (2021) investigated “whether ABCB11930_1931del TC predisposed cats to macrocyclic-lactone toxicosis and the frequency of the ABCB11930_1931del TC gene mutation in banked feline DNA samples. … 4 of the 5 cats with neurologic signs presumed to be associated with macrocyclic-lactone exposure were homozygous for ABCB11930_1931del TC. The other cat had unilateral vestibular signs not typical of macrocyclic-lactone toxicosis. … Results suggested a strong relationship between homozygosity for ABCB11930_1931del TC and neurologic toxicosis after topical application with eprinomectin-containing antiparasitic products labeled for use in cats … .”Prevalence: Mealey et al. (2021): "The distribution of genotypes from the banked feline DNA samples was as follows: 0 homozygous for ABCB11930_1931del TC, 47 heterozygous for ABCB11930_1931del TC, and 959 homozygous for the wild-type ABCB1 allele. Among the 47 cats with the mutant ABCB1 allele, only 3 were purebred (Ragdoll, Russian Blue, and Siamese)." Associated gene:
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|ABCB1||ATP-binding cassette, sub-family B (MDR/TAP), member 1||Felis catus||A2||NC_018724.3 (93334660..93099611)||ABCB1||Homologene, Ensembl, NCBI gene|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
|Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Year Published||PubMed ID(s)||Acknowledgements|
|Adverse reaction to certain drugs||ABCB1||deletion, small (<=20)||A2||c.1930_1931del TC||ABCB11930_1931del TC (cDNA reference sequence NM_001171064.2) within exon 15 results in a frameshift generating a series of stop codons immediately downstream from the deletion. The protein product is predicted to be severely truncated (~50%) and non functional. (Mealey and Burke, 2015)||2015||25660379|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Mealey, K.L., Burke, N.S., Connors, R.L. :|
|ABCB11930_1931del TC gene mutation in a temporal cluster of macrocyclic lactone-induced neurologic toxicosis in cats associated with products labeled for companion animal use. J Am Vet Med Assoc 259:72-76, 2021. Pubmed reference: 34125616. DOI: 10.2460/javma.259.1.72.|
|2015||Mealey, K.L., Burke, N.S. :|
|Identification of a nonsense mutation in feline ABCB1. J Vet Pharmacol Ther 38:429-33, 2015. Pubmed reference: 25660379. DOI: 10.1111/jvp.12212.|
- Created by Frank Nicholas on 14 Nov 2015
- Changed by Frank Nicholas on 14 Nov 2015
- Changed by Imke Tammen2 on 18 Jun 2021