OMIA:001402-9925 : Multidrug resistance 1, ABCB1-related in Capra hircus
Categories: Homeostasis / metabolism phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: unknown
Cross-species summary: MDR1
Species-specific description: Nürnberger et al. (2021): "a Thuringian goat developed ... neurological signs after treatment with doramectin, a compound from the macrocyclic lactone class. ... For diagnostic purposes, sequencing of the complete mRNA transcript coding for caprine Mdr1 was performed ... . The only position where the Mdr1 sequence from the suspected drug-sensitive goat differed was in the 3'-untranslated region, being a heterozygous single nucleotide polymorphism c.3875C>A. It can be suspected that this variant affects the expression level, stability, or translation efficiency of the Mdr1 mRNA transcript and therefore might be associated with the suspected drug sensitivity."
Breed: Thüringer Wald Ziege, Germany (Goat) (VBO_0009497).
Cite this entry
|2021||Nürnberger, D., Müller, S.F., Hamann, M., Geyer, J. :|
|First sequencing of caprine Mdr1 (Abcb1) mRNA due to suspected neurological adverse drug reaction in a Thuringian goat following extra-label use of doramectin. Front Vet Sci 8:682393, 2021. Pubmed reference: 34169111 . DOI: 10.3389/fvets.2021.682393.|
- Created by Imke Tammen2 on 01 Jul 2021
- Changed by Imke Tammen2 on 01 Jul 2021