OMIA:001402-9925 : Multidrug resistance 1, ABCB1-related in Capra hircus (goat) |
In other species: dog , domestic cat , taurine cattle
Categories: Homeostasis / metabolism phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 171050 (gene) , 120080 (trait)
Single-gene trait/disorder: unknown
Disease-related: yes
Cross-species summary: MDR1
Species-specific description: Nürnberger et al. (2021): "a Thuringian goat developed ... neurological signs after treatment with doramectin, a compound from the macrocyclic lactone class. ... For diagnostic purposes, sequencing of the complete mRNA transcript coding for caprine Mdr1 was performed ... . The only position where the Mdr1 sequence from the suspected drug-sensitive goat differed was in the 3'-untranslated region, being a heterozygous single nucleotide polymorphism c.3875C>A. It can be suspected that this variant affects the expression level, stability, or translation efficiency of the Mdr1 mRNA transcript and therefore might be associated with the suspected drug sensitivity."
Breed:
Thüringer Wald Ziege, Germany (Goat) (VBO_0009497).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001402-9925: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
2021 | Nürnberger, D., Müller, S.F., Hamann, M., Geyer, J. : |
First sequencing of caprine Mdr1 (Abcb1) mRNA due to suspected neurological adverse drug reaction in a Thuringian goat following extra-label use of doramectin. Front Vet Sci 8:682393, 2021. Pubmed reference: 34169111. DOI: 10.3389/fvets.2021.682393. |
Edit History
- Created by Imke Tammen2 on 01 Jul 2021
- Changed by Imke Tammen2 on 01 Jul 2021
- Changed by Imke Tammen2 on 16 Oct 2023