OMIA:001402-9913 : Multidrug resistance 1, ABCB1-related in Bos taurus (taurine cattle)
Categories: Homeostasis / metabolism phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: MDR1
Species-specific description: Seaman et al. (1987) describe "an unusual nervous condition in Murray Grey cattle following treatment with avermectin B1 on a farm in the central tablelands of New South Wales. Eight cattle developed severe signs of central nervous system derangement and died or were euthanased. The neurological syndrome was reproduced in a field trial using avermectin B1. ... The greater than ten-fold concentrations of avermectin B1, detected in the brains of the affected cattle compared to the normal animal suggests an excessively high concentration of the drug in the nervous system of those affected cattle. ... The farm on which the reactions occurred has maintained a virtually closed herd for approximately 15 years. ... It is possible that the affected Murray Greys in this herd had some characteristics that allowed avermectin B, to penetrate the central nervous system more readily than would normally be expected."
Have human generated variants been created, e.g. through genetic engineering and gene editing
Murray Grey (Cattle) (VBO_0000312).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
|1987||Seaman, J.T., Eagleson, J.S., Carrigan, M.J., Webb, R.F. :|
|Avermectin B1 toxicity in a herd of Murray Grey cattle. Aust Vet J 64:284-5, 1987. Pubmed reference: 3426470. DOI: 10.1111/j.1751-0813.1987.tb15963.x.|
- Created by Imke Tammen2 on 05 Mar 2021
- Changed by Imke Tammen2 on 05 Mar 2021